James Castellano, MD, PhD

  • Assistant Professor

Dr. Castellano joined the UPMC Epilepsy Division in 2018. He earned his MD and PhD from the Icahn School of Medicine at Mount Sinai in New York. He investigated the role of epigenetics in hippocampal synaptic plasticity at the National Institute on Aging before completing a residency in neurology at the Albert Einstein College of Medicine/Montefiore Medical Center in New York. He served as chief resident in his final year. He then completed a combined adult/pediatric epilepsy fellowship also at Albert Einstein College of Medicine. Dr. Castellano is currently board certified in Neurology.

Dr. Castellano currently evaluates epilepsy patients in the clinic setting and provides medical, surgical, and neuromodulatory (responsive neurostimulation, vagal nerve stimulation) treatment options. Additionally, he attends in the inpatient epilepsy monitoring unit. Dr. Castellano also provides service to both the continuous EEG monitoring and the neurophysiologic intraoperative monitoring services.

Specialized Areas of Interest:

Neurobiology of Epileptogenesis, Autoimmune Epilepsy, Medically Intractable Epilepsy

Board Certifications:

American Board of Psychiatry and Neurology - Neurology
American Board of Psychiatry and Neurology - Epilepsy

Professional Organization Membership:

American Academy of Neurology
American Epilepsy Society
American Clinical Neurophysiology Society

Selected Publications:

Castellano JF, Meyer JA, Lado FA. (2017) A Case Series of Adult-Onset Rasmussen’s Encephalitis: Diagnostic and Therapeutic Challenges. Front Neurol Oct 25; 8: 564

Castellano JF, Fletcher BR, Patzke H, Long JM, Sewal AS, Kim DH, Kelley-Bell B, Rapp PR. (2014) Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging. Hippocampus 24: 1006-1016.

Castellano JF, Fletcher BR, Kelley-Bell B, Kim DH, Gallagher M, et al. (2012) Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus. PLoS ONE 7(3): e33249.