Mohamed (Mo) F. Doheim, MD, PhD, FRCP

Research Assistant Professor of Neurology

Title(s):

Clinical Research Assistant Professor of Neurology
Founding Director, NeuroPrecision Lab
Previous NIH StrokeNet Fellow
UPMC Stroke Institute
University of Pittsburgh School of Medicine

Biographical Sketch
Mohamed (Mo) F. Doheim, MD, PhD, FRCP, is an Assistant Professor of Neurology in Clinical Research at the UPMC Stroke Institute, University of Pittsburgh School of Medicine, where he focuses on precision medicine, artificial intelligence, and innovation in acute ischemic stroke and neurological care. His research integrates clinical trial evidence, big data analytics, and AI-driven modeling to move beyond one-size-fits-all approaches toward individualized treatment selection, procedural optimization, and improved stroke systems of care. Dr. Doheim earned his MD from Alexandria University, Egypt and completed postdoctoral clinical research fellowship training and NIH StrokeNet Fellowship at the UPMC Stroke Institute, University of Pittsburgh School of Medicine. He received his PhD from Maastricht University with a dissertation titled “Beyond One-Size-Fits-All in Acute Ischemic Stroke: From Data-Driven Approaches to Personalized Clinical Decision-Making,” and he is currently pursuing a Master of Data Science at the University of Pittsburgh. He is the Founding Director and Principal Investigator of the NeuroPrecision Lab and serves as Primary Manager and Co-Investigator of the multicenter DUSK Trial, focused on distal medium vessel occlusion stroke. He is also Chief Executive Officer of HORUS NeuroTechnologies, a Pitt-licensed startup developing digital solutions and clinical decision support systems for acute neurological disorders. 
 
Dr. Doheim’s work spans endovascular therapy optimization, AI-enabled stroke triage, heterogeneity of treatment effect modeling, clinical trial design, and translational neurovascular innovation. His contributions include research on distal and medium vessel occlusion stroke, posterior circulation stroke, thrombectomy systems of care, thrombolysis strategies, and explainable counterfactual treatment estimation models. He has authored or co-authored more than 180 peer-reviewed publications and conference abstracts, including work in Annals of Neurology, Neurology, Stroke, Journal of Neurology, Neurosurgery and Psychiatry, The Lancet, The Lancet Neurology, Journal of NeuroInterventional Surgery, and other leading journals. His recent publications include studies on individualized treatment in distal and medium vessel occlusion stroke, AI-driven triage and transfer efficiency, extended-window IV thrombolysis, posterior circulation thrombectomy, and stroke systems of care. Beyond research, he is active in mentorship, teaching, peer review, and editorial leadership. He has peer-reviewed dozens of manuscripts for over 25 journals, served in editorial roles, and delivered extensive instruction in clinical research, biomedical statistics, evidence-based medicine, scientific writing, and critical appraisal. 
 
Education & Training
  • 2026–Present – Master of Data Science (MDS), University of Pittsburgh, Pittsburgh, PA, USA.
  • 2025–2026 – NIH StrokeNet Fellow, UPMC Stroke Institute, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • 2024–2026 – PhD, Neurology, Maastricht University, Maastricht, The Netherlands.
  • 2025– The American Board of Artificial Intelligence in Medicine (ABAIM), USA
  • 2026 – National Institute for Neurological Disorders and Stroke (NINDS) Clinical Trials Methodology Course (CTMC), USA.
  • 2025 – NSF I-Corps Regional Course, National Science Foundation, Cornell Research & Innovation, and University at Buffalo, USA.
  • 2022–2024 – Postdoctoral Clinical Research Fellow, UPMC Stroke Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • 2021–2022 – Clinical Intern and House Officer, Alexandria University Hospitals, Alexandria University, Egypt.
  • 2019 – Data Scientist Track via Python (26 courses), DataCamp
  • 2017–2018 – Graduate Certificate in Clinical Research, Harvard Medical School, Boston, MA, USA.
  • 2016-2017– NIH Clinical Center Six-month Online Course: Introduction to Principles and Practice of
    Clinical Research, USA
  • 2014–2021 – Doctor of Medicine (MD), Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Specialized Areas of Clinical, Research and/or Education Interests
  • Computational Neuroscience, Statistical Modeling and Advanced Machine Learning
  • Acute Ischemic Stroke
  • Endovascular Therapy
  • Neuroimaging and Stroke Biomarkers
  • Stroke Systems of Care and Artificial Intelligence in Stroke Triage
  • Clinical Trial Design and Meta-Analysis
  • Evidence-Based Medicine and Research Education
Professional Organization Membership
  • Fellow, the Royal College of Physicians (RCP)
  • American Neurological Association (ANA)
  • American Heart Association (AHA)
  • Society of Vascular and Interventional Neurology (SVIN)
  • American Academy of Neurology (AAN)
  • Harvard Alumni Association (HAA)
  • Full Member, Sigma Xi Honor Society 
Honors & Awards
  • Elected Fellow of the Royal College of Physicians (FRCP), United Kingdom (2026).
  • Annual Meeting Poster Award, Abstract of Distinction, Cerebrovascular Special Interest Group Lecture, American Neurological Association Annual Meeting (2025).
  • NIH/NINDS StrokeNet Fellowship, UPMC Stroke Institute, University of Pittsburgh School of Medicine (2025).
  • Travel Grant Award, American Neurological Association Annual Meeting (2024, 2025).
  • Young Investigator Travel Grant Award, International Stroke Conference, American Heart Association (2024).
  • Medtronic Clinical Research Fellowship Award, UPMC Stroke Institute, University of Pittsburgh School of Medicine (2023, 2024).
  • Abstract of Distinction, American Neurological Association Annual Meeting (2024).
  • Judge and Panelist Recognition Award, International Journal of Medical Students (IJMS) World Conference of Medical Student Research (2022).
  • Finalist, Inaugural SVINnovation Challenge, Society of Vascular and Interventional Neurology (SVIN) Annual Meeting (2022).
  • Trainee Travel Grant Award, Society of Vascular and Interventional Neurology Annual Meeting (2022).
  • Best Student Presentation Award, Egyptian Vascular Summit, Alexandria, Egypt (2020).
  • First Place Winner, Best Presentation Team Award, International Brain Research Organization (IBRO) School of Neuroscience, Cairo, Egypt (2018).
  • Two Full Scholarships, International Brain Research Organization (IBRO) Schools of Neuroscience, Cairo, Egypt (2018, 2020).
  • Full Scholarship, Poznan University Hospitals, Poznan, Poland (2018).
  • Scholarship Award, Dubai Harvard Foundation for Medical Research (DHFMR), Harvard Clinical Research Training Program (2017).
  • First Place Winner, Best Student Research Paper, 14th Annual Conference of the Egyptian Association for Advancement of Medical Basic Sciences (EAMBS) (2017).
Selected Recent Publications
  • Doheim MF, Mohammaden MH, Abdelhamid H, Olive-Gadea M, Rodrigo-Gisbert M, Requena M, et al. Individualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model. Annals of Neurology. 2026.
  • Doheim MF, Starr M, Bhatt NR, Rocha M, Al-Bayati AR, Sultany A, et al. Impact of an Artificial Intelligence-Driven Triage System on Workflow and Transfer Efficiency: Stratified Analysis of 4,548 Admissions to Four Thrombectomy Hubs Receiving Transfers from Sixty Spokes. Journal of Neurology, Neurosurgery & Psychiatry. 2026.
  • Doheim MF, Al-Qudah AM, Singh R, Bhatt NR, Rocha M, Wechsler LR, et al. Exploring Between-Study Heterogeneity in Extended-Window IV Thrombolysis for Acute Ischemic Stroke: A Meta-Analysis of 18 Randomized Controlled Trials. Neurology. 2026.
  • Lima JC*, Doheim MF*, Nogueira CCS, Sen S, Nogueira RG. From Gums to Brain: Unveiling the Hidden Inflammatory Connection Between Periodontal and Cerebrovascular Diseases. Stroke. 2026. (Co-first author)
  • Nogueira RG, Jovin TG, Lansberg MG, Haussen DC, Jadhav AP, Brown S, et al. Time to Treatment in Stroke Thrombectomy and Outcomes in the Extended Time Window: A Meta-Analysis. Neurology. 2026.
  • Nogueira RG, et al. Endovascular Therapy for Acute Vertebrobasilar Occlusion (VERITAS): A Systematic Review and Individual Patient Data Meta-Analysis. The Lancet. 2025.
  • Doheim MF, et al. Direct Endovascular Therapy vs Bridging Therapy in Acute Ischemic Stroke Due to M2 Segment Occlusion of the Middle Cerebral Artery: An Inverse Probability Treatment Weighting Analysis from the MR CLEAN Registry. Stroke. 2025.
  • Doheim MF, et al. Adjunctive ThromboLytics After Successful Endovascular Reperfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Annals of Neurology. 2025.
  • Doheim MF, et al. Association of Anesthesia Strategies with Outcomes in Endovascular Treatment for Distal and Medium Vessel Occlusions: A Propensity Score-Matched Analysis of the MR CLEAN Registry and Meta-Analysis. European Stroke Journal. 2025.
  • Knapen R*, Doheim MF*, Audebert HJ, Mont'Alverne F, et al. Intravenous Thrombolysis Prior to Endovascular Treatment in Basilar Artery Occlusions: A Patient-Pooled Analysis of Four Randomized Controlled Trials. Cardiovascular and Interventional Radiology. 2025. (Co-first author)
  • Doheim MF, et al. Meta-Analysis of Randomized Controlled Trials on Intravenous Thrombolysis in Minor Acute Ischemic Stroke. Neurology. 2025.
  • Doheim MF, Bhatt NR, Al-Bayati AR, Baron JC, Brainer Clares Andrade J. Advancing Precision Medicine in Acute Stroke Care: Personalized Treatment Strategies and Outcomes. Frontiers in Medicine. 2025.
  • Li W*, Doheim MF*, et al. Endovascular Treatment for Acute Posterior Circulation Tandem Occlusions: Insights from the BASILAR and PERSIST Registries. Journal of Stroke. 2025. (Co-first author)
  • Mohammaden MH*, Doheim MF*, et al. Balloon Guide Catheter Impact on Angiographic and Clinical Outcomes in Distal Medium Vessel Occlusion Stroke Thrombectomy. Journal of NeuroInterventional Surgery. 2025. (Co-first author)
  • Nogueira RG, Doheim MF, et al. Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes After Acute Ischemic Stroke: An Analysis of the DAWN Trial. Annals of Neurology. 2024.
  • GBD 2019 Stroke Collaborators (Doheim MF). Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021. Lancet Neurology. 2024.
  • Steinmetz JD, Seeher KM, Schiess N, et al. (Doheim MF). Global, Regional, and National Burden of Disorders Affecting the Nervous System, 1990-2021. Lancet Neurology. 2024.
  • Nogueira RG, et al. (Doheim MF). Higher Procedural Volumes Are Associated with Faster Treatment Times, Better Functional Outcomes, and Lower Mortality in Patients Undergoing Endovascular Treatment for Acute Ischemic Stroke. Annals of Neurology. 2023.
  • Doheim MF, Hagrass AI, Elrefaey M, Al-Bayati AR, Bhatt NR, Lang M, et al. Intracranial Stenting Versus Aggressive Medical Therapy for Symptomatic Intracranial Stenosis: A Meta-Analysis of Multicenter Randomized Controlled Trials. Interventional Neuroradiology. 2023.
  • Doheim MF, Hagrass AI, Elrefaey M, Al-Bayati AR, Bhatt NR, Lang M, et al. From Therapeutic Nihilism to Armamentarium: A Meta-Analysis of Randomized Clinical Trials Assessing Safety and Efficacy of Endovascular Therapy for Acute Large Ischemic Strokes. Interventional Neuroradiology. 2023.
Doheim, Mohamed
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