Dr. Bhuiyan’s research interests focus on ionic dysregulation and neurodegeneration associated with ischemic stroke, and vascular contributions to cognitive impairments and dementia (VCID). In particular, the goal of his research is to identify the pathogenic mechanisms on how ion transporter proteins and their upstream kinases (such as WNK, SPAK/OSR1 etc) play role in brain cell death in response to ischemia that give rise to neurological and cognitive deficits. These findings are used to identify potential targets for the development of therapeutic interventions for ischemic stroke, VCID and vascular dementia.
Education & Training
- MSc, Asian Institute of Technology, Thailand, Food Engineering and Biotechnology
- PhD, The University of Science & Technology, South Korea, Biomolecular Science
- Postdoctoral, Catholic University of Korea, South Korea, Neuropharmacology
- Postdoctoral, University of Pittsburgh, Neurology
Specialized Areas of Clinical, Research and/or Educational Interests
- Research: Ischemic stroke; Cerebral ischemia; Vascular dementia
- Education: Research Training
Professional Organization Membership
- American Stroke Association
- American Heart Association
- Society for Neuroscience
Honors & Awards
- Received 2020 Young Investigator Contest Best Award, The Veterans Research Foundation of Pittsburgh, Pittsburgh, PA.
Selected Recent Publications
Zhang J*, Bhuiyan M.I.H.*, Zhang T*, Karimy JK, Wu Z, Pigott VM, Zhang J, Huang H, Hassan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, Hitchens TK, Minnigh MB, Poloyac SM, Alper SL, Molyneaux BJ, Trevelyan AJ, Kahle KT, Sun D, and Deng X. Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications 11, 2020.
Huang H, Bhuiyan M.I.H., Jiang T, Shanshan S, Shankar S, Taraneh T, Eric L, Schreppel P, Hintersteininger M, Yang SS, Lin SH, Molyneaux BJ, Zhang Z, Erker T, Sun D. A novel NKCC1 inhibitor STS66* reduces brain damage in mice after ischemic stroke. Stroke 50: 1021-1025, 2019.
Bhuiyan M.I.H., Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. J Cereb Blood Flow Metab 37: 2780–2794, 2017.
Bhuiyan M.I.H., Kim J.C., Hwang S.N., Lee M.Y, and Kim S.Y. Ischemic tolerance is associated with VEGF-C and VEGFR-3 signaling in the mouse hippocampus, Neuroscience 290: 90-102, 2015.
Bhuiyan M.I.H., Islam M.N, Jung S.Y, Yoo H.H, Lee Y.S, and Jin C. Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats, Biological & Pharmaceutical Bulletin 33: 11-17, 2010.