Dr. Graham is the Director of the Geriatric Research, Educational and Clinical Center (GRECC) at the VA. The GRECC is a multidepartmental center that aims to develop new treatments, educate providers and students and pilot new methods of delivering clinical care for elderly Veterans. The research foci of the GRECC include stroke, traumatic brain injury, Alzheimer’s disease, communication disorders, and cardiac rehabilitation. Dr. Graham is also serving as Associate Chief of Staff for Research at the VA. As Vice-chair for Research of the Department of Neurology, he oversees the rapidly growing research program of the Department. Dr. Graham precepts medical students and residents on the inpatient services at the VA. He is also a staff neurologist at the VA with a special interest in stroke and dementia.
Dr. Graham’s research focuses on the mechanisms by which neurons die after stroke and brain trauma. Ongoing research projects address the role of the protein, UCH-L1 also known as Parkin 5 in stroke, traumatic brain injury and neurodegeneration. UCHL1 activity is required to maintain axonal transport and synaptic function. New findings this year have shown that axonal injury in mice with traumatic brain injury may be reduced by treatment with a novel protein fusing UCHL1 and elements of the prothrombin domain of the HIV capsid protein TAT. This novel protein readily enters the brain and neurons when given systemically. These and other findings lead to the funding of new R01 award from NIH NINDS to explore the role of UCHL1 in the pathogenesis and treatment of TBI.
Professional Organization Membership
Society for Neuroscience
American Academy of Neurology
National Stroke Council, American Heart Association
National Stroke Association
- Journal of Cerebral Blood Flow and Metabolism
- Ad Hoc Reviewer:
- Annals of Neurology
- Brain Research
- Experimental Neurology
- Journal of Neurochemistry
- Journal of Neuroscience
Dr. Graham's publications can be reviewed through the National Library of Medicine's publication database.