Caixia Chen

Research Instructor

Biographical Sketch 

Dr. Chen works on molecular therapies aimed at promoting repair and recovery following traumatic brain injury, stroke, and anxiety/depress, with a focus on the impact of specific gene expression and drug treatment, as well as investigation the mechanisms through which drugs exert protective effects. Her research involves cell culture, the development of cellular and animal pathology models of central nervous system disorders, immunochemistry, neurological behavior analysis, and more. With a diverse background in laboratory and industrial research, Dr. Chen’s expertise spans many fields including microbiology, biochemistry, pharmacology and molecular biology.  Dr. Chen is also interested in developing high-throughput drug screening model for infectious, cancer and neurological diseases, discovering bioactive lead compounds and investigating their mechanisms of action, as well as exploring the impact of gut microbiome on disease progression and drug efficacy.

Education & Training

  • Post-Doctoral, Institute of Microbiology, Chinese Academy of Sciences
  • Ph.D. , Microbial and Biochemical Pharmaceutical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
  • B.S. , Pharmacy,  Shandong Medical University

Specialized Areas of Clinical, Research and/or Education Interests

Research: Stroke; Traumatic Brain Injury; Neuroinflammation; discovery of bioactive natural product; drug screening; chemical and pharmaceutical analysis

Board Certifications

Reviewer, Applied Microbiology and Biotechnology/ Phytotherapy Research/ Chemico-Biological interactions/ Oncology Reports/ Plant Medica/Molecular Medicine Reports/Chemistry and Biodiversity/ Evidence-based Complementary and Alternative Medicine/ Experimental and Therapeutic Medicine

Selected Recent Publications

  1. Wenxuan Han, Hongjian Pu, Sicheng Li, Yaan Liu, Yongfang Zhao, Mingyue Xu, Caixia Chen, Yun Wu, Tuo Yang, Qing Ye, Hong Wang, R Anne Stetler, Jun Chen, Yejie Shi. Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke.  Journal of Neuroinflammation. 2023,20(1): 178.
  2. Yongfang Zhao , Cheng MaCaixia ChenSicheng LiYangfan WangTuo YangR Anne StetlerMichael V L BennettC Edward DixonJun ChenYejie Shi. .STAT1 contributes to microglial/macrophage inflammation and neurological dysfunction in a mouse model of traumatic brain injury. Journal of Neuroscience. 2022, 42(39):7466-7481.
  3. Caixia Chen, Xiangyin Chen, Biao Ren,  Hui Guo, Wael M Abdel-MageedXueting LiuFuhang SongLixin Zhang. Characterization of Streptomyces sp. LS462 with high productivity of echinomycin, a potent antituberculosis and synergistic antifungal antibiotic. Journal of Industrial Microbiology and Biotechnology. 2021 48(9-10): kuab079.
  4. Annette S Wilson, Kathryn R Koller, Matsepo C Ramaboll, Lucky T Nesenganl, Soeren Ocvirk, Caixia Chen, Christie A Flanagan, Flora R Sapp, Zoe T Merritt, Faheem Bhatti, Timothy K Thomas, Stephen J D O’Keefe. Diet and the human gut microbiome: An international review. Digestive Diseases and Science. 2020, 65:723-740