Title(s)
- Chief, Neuromuscular Division
- Director, MDA Care Center
- Co-Director, EMG Laboratory, UPMC Presbyterian
- Associate Editor, Journal of Clinical Neuromuscular Disease
Biographical Sketch
Dr. Lacomis’ practice is focused on the clinical, electrodiagnostic, and pathologic aspects of neuromuscular diseases. Particular areas of research as well as clinical expertise include myasthenia gravis, amyotrophic lateral sclerosis, and muscle diseases. Teaching and administrative activities are integrated within his subspecialty.
Education & Training
- Senior Fellow, University of Massachusetts Medical Center, Neuromuscular Diseases and Electromyography
- Fellow, University of Massachusetts Medical Center, Neuromuscular Diseases, Electromyograph, Neuropathology
- Resident, Harvard Longwood Program, Neurology
- Resident, Pennsylvania State University, Internal Medicine
- MD, Pennsylvania State University
Specialized Areas of Clinical, Research and/or Educational Interests
- Research: ALS (drug trials, technology, biomarkers, genetic causes, epidemiology); Myasthenia gravis (outcomes, drug trials); Critical illness neuromuscular diseases; Autoimmune myopathies
- Clinical: Myasthenia gravis; Muscle diseases; Electromyography; Neuromuscular Pathology
- Education: Electrodiagnostic testing; Neuromuscular diseases; Neuromuscular pathology
- Teaching: electrodiagnostic testing, neuromuscular diseases, neuromuscular pathology
Board Certifications
- American Board of Psychiatry and Neurology: Neurology
- American Board of Psychiatry and Neurology: Added Qualifications in Clinical Neurophysiology
- American Board of Psychiatry and Neurology: Neuromuscular Medicine
- American Board of Electrodiagnostic Medicine
Professional Organization Membership
- American Academy of Neurology, Fellow
- American Association of Electrodiagnostic Medicine, Fellow
- American Neurological Association
Honors & Awards
- Pittsburgh Magazine, named “Top Doctors”
- Teaching award for medical student education at Brigham & Women's Hospital
- Excellence in Teaching Award from Neurology residents (UPMC)
- Castle Connolly Medical, Inc., named “America’s Top Doctors”
- Elected to American Neurological Association
Selected Recent Publications
Isfort M, McVerry BJ, Shutter L, Kim M, Lacomis D. Perceived utility of electrodiagnostic testing in critical illness myopathy and polyneuropathy: A survey of intensive care unit providers. Muscle Nerve. 2022 Jul;66(1):90-95. doi: 10.1002/mus.27561. Epub 2022 May 6. PMID: 35470438.
Kocoloski A, Martinez S, Moghadam-Kia S, Lacomis D, Oddis CV, Ascherman DP, Aggarwal R. Role of Intravenous Immunoglobulin in Necrotizing Autoimmune Myopathy. J Clin Rheumatol. 2022 Mar 1;28(2):e517-e520. doi: 10.1097/RHU.0000000000001786. PMID: 34581697.
Donohue C, Carnaby G, Reilly MC, Colquhoun RJ, Lacomis D, Garand KLF. A meta-analysis of post-exercise outcomes in people with amyotrophic lateral sclerosis. eNeurologicalSci. 2023 Feb 21;31:100452. doi: 10.1016/j.ensci.2023.100452. PMID: 36875937; PMCID: PMC9982645.
Lacomis D. What Is in the Myopathy Literature? J Clin Neuromuscul Dis. 2023 Mar 1;24(3):130-139. doi: 10.1097/CND.0000000000000440. PMID: 36809200.
Dwairi V, Giacobbe A, Zivkovic S, Lacomis D. Diagnosing X-linked myopathy with excessive autophagy after 30 years: Genetic, ultrasonographic, and electrodiagnostic findings. J Clin Neuromuscl Dis 2024;26:12-15. PMID: 39163157
Ambrocio KR, Aggarwal R, Lacomis D, Zhang X, Garand KL. Features of swallowing function in sporadic inclusion body myositis: preliminary evidence using well-tested assessment frameworks. Am J Speech Lang Pathol. 2024;33(6):2793-2804. PMID: 39392897.
Kacker K, Chetty N, Feldman AK, Bennett B, Yoo PE, Fry A, Lacomis D, Harel NY, Nogueira RG, Majidi S, Opie NL, Collinger JL, Oxley TO, Putrino DF, Weber DJ. Motor activity in gamma and high gamma bands recorded with a Stentrode from the human motor cortex in two people with ALS. J. Neural Eng. J Neural Eng. 2025;22(2):026036. doi: 10.1088/1741-2552/adbd78. PMID: 40048825; PMCID: PMC11956166.
Homayoun H, DeChellis-Marks MR, Kofler J, Fricklaas G, Gleixner AM, Cheng Yah F, Lacomis D, Chu CT, Donnelly CJ. Novel kinesin family 1A variants linked to atypical parkinsonism elicit altered neuronal tdp-43 interactions and dendritic atrophy. Am J Pathol 2025 Jun 19:s0002-9440(25)00204-4. Doi 10.1016/j.ajpath.2025.05.018.
