Feng Zhang, PhD

Assistant Professor of Neurology

Biographical Sketch

Dr. Feng Zhang received his MD from Henan Medical University and his PhD from Shanghai Medical University in China. He completed his postdoctoral trainings in the National Institutes of Health and Pennsylvania State University. Dr. Zhang is currently an Assistant Professor at the Department of Neurology, University of Pittsburgh School of Medicine. His research focuses on cerebral ischemia and vascular dementia, which is supported by the American Heart Association and the National Institutes of Health. He has published more than 70 peer-reviewed papers in reputed journals and has been serving as an editorial board member of two journals.

Education & Training

  • PhD, Shanghai Medical University, Medicine
  • MD, Henan Medical University, Medicine

Specialized Areas of Research

Research:  Role of Nrf2 pathway in the brain disorders; Protection and mechanisms of ischemic preconditioning; Vascular dementia; Hemorrhagic transformation

Professional Organization Membership

  • Society for Neuroscience
  • International Society for Cerebral Blood Flow & Metabolism
  • American Heart Association, Stroke Council
  • Society for Redox Biology and Medicine

Honors & Awards

  • NIH Visiting Fellow Award
  • AHA National SDG Award 
  • Visiting Professor, Zhengzhou University
  • Visiting Professor, Tai’an Medical University
  • Visiting Professor, State Key Laboratory of Medical Neurobiology

Selected Recent Publications

Zhang M, Wang S, Mao L, Leak RK, Shi Y, Zhang W, Hu X, Sun B, Cao G, Gao Y, Xu Y, Chen J, Zhang F. Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. J Neurosci. 2014 Jan 29;34(5):1903-15. doi: 10.1523/JNEUROSCI.4043-13.2014. PMID: 24478369; PMCID: PMC3905150.

Yang T, Sun Y, Mao L, Zhang M, Li Q, Zhang L, Shi Y, Leak RK, Chen J, Zhang F. Corrigendum to "Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation" [Redox Biol. 17 (2018) 323-337]. Redox Biol. 2019 Apr;22:101067. doi: 10.1016/j.redox.2018.101067. Epub 2018 Dec 21. Erratum for: Redox Biol. 2018 Jul;17:323-337. PMID: 30580978; PMCID: PMC6435945.

Mao L, Yang T, Li X, Lei X, Sun Y, Zhao Y, Zhang W, Gao Y, Sun B, Zhang F. Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway. J Cereb Blood Flow Metab. 2019 Feb;39(2):352-366. doi: 10.1177/0271678X18764083. Epub 2018 Mar 13. Erratum in: J Cereb Blood Flow Metab. 2019 Feb;39(2):371. PMID: 29533123; PMCID: PMC6365596.

Liu H, Povysheva N, Rose ME, Mi Z, Banton JS, Li W, Chen F, Reay DP, Barrionuevo G, Zhang F, Graham SH. Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4643-4650. doi: 10.1073/pnas.1821282116. Epub 2019 Feb 13. PMID: 30760601; PMCID: PMC6410860.

Yang T, Sun Y, Li Q, Li S, Shi Y, Leak RK, Chen J, Zhang F. Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2. Exp Neurol. 2020 Mar;325:113142. doi: 10.1016/j.expneurol.2019.113142. Epub 2019 Dec 5. PMID: 31812555; PMCID: PMC6953417.