Biographical Sketch
Dr. Appleberry is an assistant professor of neurology and joined the University of Pittsburgh Department of Neurology in August of 2022. She sees the full spectrum of central nervous system (CNS) inflammatory disorders and genetic CNS demyelinating disorders, including CADASIL and variants, Col4A1 cerebral microangiopathy, LMNB1-related Autosomal Dominant Adult Leukodystrophy (ADLD), and others. She launched an undiagnosed CNS white matter disease clinic in 2022 and is studying the impact of Variants of Uncertain Significance (VUS) in undercharacterized conditions.
Current Studies
- Semaphorin 4A as a Biomarker for CNS Demyelination, Co-Principal Investigator
- Assessing Clinical Significance of Variants of Uncertain Significance
- Use of Dalfampridine in LMNB1-Related Autosomal Dominant Adult Leukodystrophy
Service
- AAN Guidelines Subcommittee
- AAN Research Program Reviewer
- Peer Reviewer for Neurology Genetics, Frontiers in Neurology, Child Neurology
- Allegheny County Delegate, Pennsylvania Medical Society
Education & Training
- NeuroNEXT Clinical Trials Fellowship, University of Pittsburgh
- Health Sciences Leadership Academy for Early Career Faculty, University of Pittsburgh
- Fellow, Medstar Georgetown University Hospital, Neuroimmunology/MS
- Resident, Penn State University, Neurology
- MBA, Rockhurst University Helzberg School of Management
- DO, Kansas City University College of Medicine and Biosciences
- BS, Wells College and University of Denver, Chemistry
Board Certification
American Board of Psychiatry and Neurology, 2021
Selected Publications
Clinical Practice Guidelines for the Diagnosis, Management, and Surveillance of LMNB1-Related Autosomal Dominant Leukodystrophy. Neurology Genetics. 2025 Aug 29;11(5):e200287. doi: 10.1212/NXG.0000000000200287.
Multiple Sclerosis Management: Current Clinical Approaches to Disease-Modifying Therapy. Current Physical Medicine and Rehabilitation Reports. DOI:10.1007/s40141-022-00359-2
An Atypical Case of Respiratory Syncytial Virus (RSV) Associated Encephalitis in an Immunocompetent Patient. Neurology.
Report of a Child With Febrile Status Epilepticus and Post-COVID Multi-System Inflammatory Syndrome. Child Neurol Open. 2021 Jul 5;8:2329048X211027725. doi: 10.1177/2329048X211027725.
Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes. J Autoimmun. 2013 Feb;40:111-21. doi: 10.1016/j.jaut.2012.09.001.
Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile. J Autoimmun. 2012 Jun;38(4):293-303. doi: 10.1016/j.jaut.2011.12.005.
