Holly C. Appleberry, DO, MBA

  • Assistant Professor

Biographical Sketch

Dr. Appleberry is an assistant professor of neurology and joined the University of Pittsburgh Department of Neurology in August of 2022. She completed medical school at Kansas City University of Medicine and Biosciences followed by neurology residency at Penn State Health and neuroimmunology/MS fellowship at Georgetown University. Dr. Appleberry is a board-certified neurologist and treats patients with multiple sclerosis, neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody-associated disease, transverse myelitis, optic neuritis, neurosarcoidosis, neuro-Behcet’s disease, autoimmune encephalitis, and CNS vasculitis. She is passionate about helping her patients achieve their best and ensuring that their complex needs are met. Other interests include clinical trials, patient advocacy, and healthcare policy.

Education & Training

  • Fellow, Georgetown University, Neuroimmunology/MS
  • Resident, Penn State University, Neurology
  • MBA, Rockhurst University Helzberg School of Management
  • DO, Kansas City University College of Medicine and Biosciences
  • BS, Wells College and University of Denver, Chemistry

Specialized Areas of Clinical, Research and/or Educational Interests

  • Multiple sclerosis, neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody-associated disease, transverse myelitis, optic neuritis, neurosarcoidosis, neuro-Behcet’s disease, autoimmune encephalitis, and CNS vasculitis
  • Precision medicine, patient advocacy, and healthcare policy at the legislative leve

Board Certifications

  • American Board of Psychiatry and Neurology
  • Pennsylvania Medical License
  • Virginia Medical License
  • Maryland Medical License
  • Washington, DC Medical License

Professional Organization Membership

  • National MS Society
  • MS Association of America
  • American Academy of Neurology
  • Pennsylvania Osteopathic Medical Association
  • American Osteopathic Association
  • Physicians for Social Responsibility
  • Gold Humanism Honor Society

Honors & Awards

  • Consortium of Multiple Sclerosis Centers (CMSC) Scholarship, 2022
  • Resident Scholar of the Year, Penn State University, 2020-2021
  • Michael F. Avallone, Sr. DO Scholarship for Outstanding Advocacy, Penn State University
  • Paws Up Award, Penn State University, Excellence in Patient Care
  • Gold Humanism Honor Society, Kansas City University, 2016
  • Mineral Area Scholarship, Kansas City University
  • Cum laude and Distinction in Chemistry, Wells College and University of denver
  • Summer Research Grant, University of Denver
  • James and Nellie Westlake Scholarship (full tuition)
  • Henry Wells Scholarship
  • Opal Huffman Scholarship
  • CRC Press Freshman Chemistry Award

Selected Recent Publications

Appleberry HC, Begezda A, Cheung H, Zaghab-Mathews S, Mainali G. Report of a Child With Febrile Status Epilepticus and Post-COVID Multi-System Inflammatory Syndrome. Child Neurol Open. 2021 Jul 5;8:2329048X211027725. doi: 10.1177/2329048X211027725. PMID: 34285930; PMCID: PMC8261841.

Liubchenko GA, Appleberry HC, Striebich CC, Franklin KE, Derber LA, Holers VM, Lyubchenko T. Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes. J Autoimmun. 2013 Feb;40:111-21. doi: 10.1016/j.jaut.2012.09.001. Epub 2012 Oct 8. PMID: 23058039; PMCID: PMC3546227.

Liubchenko GA, Appleberry HC, Holers VM, Banda NK, Willis VC, Lyubchenko T. Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile. J Autoimmun. 2012 Jun;38(4):293-303. doi: 10.1016/j.jaut.2011.12.005. Epub 2012 Feb 24. PMID: 22365785; PMCID: PMC3358596.