J. Timothy Greenamyre, MD, PhD

  • Professor of Neurology
  • Chief, Movement Disorders Division
  • Director, Pittsburgh Institute for Neurodegenerative Diseases (PIND)
  • Scientific Director, University of Pittsburgh Tsinghua University Scholars Program
  • Love Family Professor and Vice-Chair for Academic Affairs

J. Timothy Greenamyre, MD, PhD, is a professor of neurology, UPMC endowed chair & chief of Movement Disorders, and director of the Pittsburgh Institute for Neurodegenerative Diseases (PIND) and the American Parkinson Disease Association Advanced Center for Parkinson’s Disease Research at the University of Pittsburgh. He is a member of the scientific advisory board of the Michael J. Fox Foundation, and a member of the scientific advisory committees of the Cure Parkinson’s Project, and the Parkinson’s Disease Foundation.

Dr. Greenamyre received his BS from Michigan State University and his MD and PhD from the University of Michigan. After his neurology residency at the University of Michigan, he joined the faculty of the University of Rochester in 1990, and was recruited to Emory University in 1995. He moved to the University of Pittsburgh in 2005. 

He received the Roland B. Mackay Award (1986) and a research fellowship award (1990-1993) from the American Academy of Neurology and he was a Mallinckrodt Scholar (1994-1997). He chaired the research grants subcommittee of the Huntington’s Disease Society of America and was a member of the NIH Parkinson’s disease research agenda planning committee, the Parkinson’s disease implementation committee and the Neurological Sciences and Disorders B study section of the NINDS. 

Dr. Greenamyre has received numerous honors, including the Langston Award from the Michael J. Fox Foundation. He delivered a 'Decade of the Brain Lecture' at the annual meeting of the American Academy of Neurology and a Presidential Lecture at the annual meeting of the Society for Neuroscience. 

The Greenamyre lab is interested in mechanisms that cause nerve cell death in disorders such as Parkinson's, Huntington's and Alzheimer's diseases. With respect to Parkinson’s disease, he is interested in interactions between environmental toxins (natural or man-made) and genes that increase or decrease an individual’s susceptibility to developing the disease. The work focuses on mitochondrial impairment, oxidative damage, and protein aggregation. 

In Huntington’s disease, his lab focuses on mitochondrial calcium handling and proteomics. The general strategy is to define mechanisms that cause nerve cell death, and then use them as potential ''targets'' for therapeutic intervention. The lab employs in vivo models of neurodegeneration and in vitro culture of cells and brain slices to study mechanisms of degeneration with a variety of biochemical, anatomical and physiological techniques.

Board Certifications

American Board of Psychiatry & Neurology

Professional Organization Membership

American Academy of Neurology
American Neurological Association
Huntington Study Group
Movement Disorders Society
Parkinson Study Group
Society for Neuroscience

Editorial Service

  • Editorial Service: 
    • Neurobiology of Disease
    • The Journal of Neuroscience 
    • Movement Disorders
    • Experimental Neurology
    • Neurochemistry & Molecular Neurobiology, Functional Neurology
  • Ad Hoc Reviewer:
    • Cell
    • Journal of Biological Chemistry
    • Nature Medicine
    • Nature Neuroscience
    • Neuron
    • Proceedings of the National Academy of Sciences
    • Science

Representative Publications

Dr. Greenamyre's publications can be reviewed through the National Library of Medicine's publication database.

Research Interest Summary

Parkinson’s disease; Huntington’s disease; tremor; dystonia.