James F. Castellano, MD, PhD

Assistant Professor of Neurology

Biographical Sketch

Dr. Castellano joined the UPMC Epilepsy Division in 2018. He earned his MD and PhD from the Icahn School of Medicine at Mount Sinai in New York. He investigated the role of epigenetics in hippocampal synaptic plasticity at the National Institute on Aging before completing a residency in neurology at the Albert Einstein College of Medicine/Montefiore Medical Center in New York. He then completed a combined adult/pediatric epilepsy fellowship also at Albert Einstein College of Medicine. Dr. Castellano is currently board certified in Neurology and Epilepsy.

Education & Training

  • Fellow, Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, NY, Epilepsy
  • Resident, Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, NY, Neurology
  • Intern, Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, NY, Medicine
  • MD, PhD, Icahn SOM at Mount Sinai - New York, NY, Medicine

Specialized Areas of Clinical, Research and/or Educational Interests 

  • Research: Epigenetics; Epileptogenesis; Pharmacoresistant Epilepsy
  • Clinical: Critical Care EEG; Neurophysiologic Intraoperative Monitoring; Epilepsy Surgery

Board Certifications

  • American Board of Psychiatry and Neurology:  Neurology
  • American Board of Psychiatry and Neurology:  Epilepsy

Professional Organization Membership

  • American Academy of Neurology
  • American Epilepsy Society
  • American Clinical Neurophysiology Society
  • American Medical Association

Honors & Awards

  • NeuroNext Fellowship
  • American Epilepsy Society Fellows Program
  • Leo M. Davidoff Medical Student Teaching Award
  • Resident Scholarship to the AAN Meeting 
  • Outstanding Intern Award in Preliminary Medicine

Selected Recent Publications

Castellano JF, Fletcher BR, Patzke H, Long JM, Sewal AS, Kim DH, Kelley-Bell B, Rapp PR. (2014) Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging. Hippocampus 24: 1006-1016.

Castellano JF, Fletcher BR, Kelley-Bell B, Kim DH, Gallagher M, Rapp PR. Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus. PLoS One. 2012;7(3):e33249. doi: 10.1371/journal.pone.0033249. Epub 2012 Mar 15. PMID: 22438904; PMCID: PMC3305324.

Castellano JF, Meyer JA, Lado FA. A Case Series of Adult-Onset Rasmussen's Encephalitis: Diagnostic and Therapeutic Challenges. Front Neurol. 2017 Oct 25;8:564. doi: 10.3389/fneur.2017.00564. PMID: 29118737; PMCID: PMC5660978.

Melachuri SR, Stopera C, Melachuri MK, Anetakis K, Crammond DJ, Castellano JF, Balzer JR, Thirumala PD. The efficacy of somatosensory evoked potentials in evaluating new neurological deficits after spinal thoracic fusion and decompression. J Neurosurg Spine. 2020 Mar 6:1-6. doi: 10.3171/2019.12.SPINE191157. Epub ahead of print. PMID: 32114528.