Dr. Yin’s research interest is to study the cellular & molecular mechanisms and therapeutic strategies of cerebrovascular and neural dysfunction after ischemic stroke, and traumatic brain injury by using state-of-the-art cell biology, molecular biology, biochemistry, pharmacology, morphology, imaging, behavior and transgenic animal approaches. Currently, major ongoing research activities in Dr. Yin’s laboratory focus on investigating how non-coding RNAs and Krüppel-like transcription factors regulate neurovascular pathophysiology affect neurological outcomes and modulate brain repair and functional recovery after ischemic stroke and traumatic brain injury. The long-term research goal of Dr. Yin’s laboratory is to discover novel molecular or pharmaceutical targets for the development of effective vaso-/neuro-protective or neurorestorative therapies against ischemic stroke and traumatic brain injury.
Education & Training
- MD, Yangzhou University Medical College, Clinical Medicine
- MS, Nanjing Medical University, Neuroscience
- PhD, Fudan University Shanghai Medical College, Neuroscience
Specialized Areas of Clinical, Research and/or Educational Interests
- Research: Transcription factors; Non-coding RNAs; BBB dysfunction and recovery; Neurovascular injury and protection; Neurovascular remodeling and repair
Professional Organization Membership
- Society for Neuroscience (SFN)
- American Heart Association (AHA)/ American Stroke Association (ASA)
- International Society of Cerebral Blood Flow and Metabolism (ISCBFM)
Honors & Awards
- Beginning Grant-in-Aid Award, American Heart Association
- Scientist Development Grant Award (National), American Heart Association
- The Investigator Award, European Stroke Research Foundation
Yang X, Tang X, Sun P, Shi Y, Liu K, Hassan SH, Stetler RA, Chen J, Yin KJ. MicroRNA-15a/16-1 antagomir ameliorates ischemic brain injury in experimental stroke. Stroke 2017 Jul; 48(7):1941-1947.
Tang X, Liu K, Hamblin MH, Xu Y, Yin KJ. Genetic deletion of Krüppel-Like Factor 11 aggravates ischemic brain injury. Molecular Neurobiology 2018 Apr;55(4):2911-2921.
Sun P, Zhang K, Hassan SH, Zhang X, Tang X, Pu H, Stetler RA, Chen J, Yin KJ. Endothelium-targeted deletion of microRNA-15a/16-1 promotes post-stroke angiogenesis and improves long-term neurological recovery. Circulation Research 2020 Mar 5. doi: 10.1161/CIRCRESAHA.119.315886. [Epub ahead of print].
Ma F, Sun P, Zhang X, Hamblin MH, Yin KJ. Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke. Science Signaling 2020 April 7 doi: 10.1126/scisignal.aay5686.
Zhang X, Tang X, Ma Feifei, Fan Y, Sun P, Zhu T, Zhang J, Hamblin MH, Chen YE, Yin KJ. Endothelium-targeted overexpression of Krüppel-like factor 11 protects blood-brain barrier function after ischemic brain injury. Brain Pathology 2020 Mar 20. doi: 10.1111/bpa.12831. [Epub ahead of print].