Laurie Knepper, MD

Associate Professor of Neurology


  • Director, Neurology Clerkship
  • Vice Chair of Education, Neurology

Biographical Sketch

Dr. Knepper completed a stroke fellowship at UPMC and helped to start the UPMC stroke service where she was a lead investigator of many pivotal stroke trials.  Dr. Knepper opened a general neurology practice, Neurology in the Berkshires, in Lenox, Massachusetts.  She returned to University of Pittsburgh School of Medicine in 2011 and joined the headache division.  

She has a continued interest in medical education, as neurology clerkship director.  Completing extensive curriculum development and restructuring, Dr. Knepper served as the chair of a task force reviewing the integration of radiology throughout the four-year medical school program as well as developing new interactive online teaching tools. Dr. Knepper is a group leader in the integrated clinical science course and teaches in small groups in the neuroscience course, as well as a member of the Promotions committee, the retention committee, the learning environment committee and the curriculum committee.  She is the current chair of the 4th year elective subcommittee. Dr. Knepper has mentored numerous neurology residents and medical students and has been teaching competency based medical education for the past 5 years with presentations at AAMC, ICBME meetings. She is also a core member of the Women in Neurology group.

Education & Training

  • MD, University of Pittsburgh School of Medicine, Medicine
  • Resident, University of Iowa Hospitals and Clinics, Neurology
  • Fellow, University of Pittsburgh Medical Center, Stroke

Specialized Areas of Clinical & Educational Research

  • Clinical: Standardized patient and Hybrid simulation; Hormones and Migraine Management; AAMC Core Entrustable Professional Activities 
  • Education: Competency Based Medical Educator; Medical School Curriculum Reform

Board Certifications

  • American Board of Psychiatry and Neurology - Neurology
  • American Board of Psychiatry and Neurology – Vascular Neurology
  • UCNS Headache Medicine Board Certification 

Honors & Awards

  • Preceptor of the Year Award, University of Pittsburgh School of Medicine, 2020
  • Preceptor of the Year Award, University of Pittsburgh School of Medicine, 2015
  • Academy of Neurology Clerkship Director Award
  • Neurology Resident Research Award, University of Iowa Hospitals and Clinics
  • Best Doctors in Pittsburgh 

Selected Publications

Aziz Y, Knepper L, Lieberman F, Drappatz J, Wiley C, Mettenberg J: Brainstem Anaplastic Astrocytoma, IDH-Mutant, WHO Grade III, Presenting with Multiple Cranial Nerve Palsies and Diffuse Neuroaxis Leptomeningeal Involvement.  P 4.008 Neurology, April 2020

Knepper, LE: University of Pittsburgh Neurology Clerkship Core EPA Self Reflection AAMC- Learn, Serve Lead, Academic Med; Nov 2016: RIME supplement

Knepper, LE, Yanta C, Safier R, Levin A, Ojha A, Stakic S, Littleton B: Assessment of medical Student Electronic Health Record Documentation – assessing 3 Core Entrustable Professional activities during the Neurology Clerkship at the University of Pittsburgh School of Medicine 2018 World Summit on Competency Based medical Education , August 24, 2018, Basel Switzerland

Niksefat M, Albashiti B, Burke D, Moshayedi P, Patira R, Knepper L :Extensive meningeal enhancement in acute central nervous system Lyme: Case series and review of literature. J Clin Neurosci. 2019 Jun; 64:25-27. doi: 10.1016/j.jocn.2019.03.048. Epub 2019 Apr 2