Title:
Neuro-oncologist
Biographical Sketch
Dr. Nisnboym Ziv is an assistant professor of neurology and medicine at the University of Pittsburgh School of Medicine. She specializes in the treatment of primary central nervous system tumors, and neurological complications of cancer treatment. Her research interests include understanding the immune landscape of CNS tumors and the development of novel therapies and imaging modalities. Her work has been presented nationally and internationally and has resulted in well recognized manuscripts, book chapter and abstracts. She serves as a peer reviewer for multiple journals and as a member of the NCI cancer prevention and control (CPC) Central Institutional Review Board (CIRB).
Education & Training
- M.D., Hadassah Medical School, The Hebrew University of Jerusalem, Israel, 2015
- M.D. Residency, Neurology Residency, The Department of Neurology, Tel-Aviv Sourasky Medical Center, Israel, 2021
- Research Fellow, UPMC Children’s Hospital, University of Pittsburgh, 2022
- Clinical Fellow - Neuro oncology, Neuro-oncology Program, Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, 2023
- Clinical Fellow - Neuro oncology, Neuro-oncology Program, Preston Robert Tisch Brain tumor center, Duke University, Durham, NC, 2024
Specialized Areas of Clinical, Research and/or Education Interests
Clinical
Dr. Nisnboym Ziv specializes in the field of neuro-oncology, treating primary and metastatic brain and spine tumors and addressing neurologic complications of cancer.
Her translational interests involve Novel Therapies for Brain and Spine Tumors, adolescent and young adult (AYA) low- and high-grade gliomas, and novel imaging modalities.
Research
Dr. Nisnboym Ziv's areas of research involve the development of novel therapies and imaging modalities, as immuno-PET tracers, for brain tumors. Her research work focuses on understanding the immune landscape of CNS tumors.
Education
Dr. Nisnboym Ziv is involved in medical student, resident and fellow clinical education. She aspires to drive the academic culture forward and create an environment where future young professionals can thrive.
Board Certifications
- Board-certified neurologist by the state of Israel
- Board eligible - United Council for Neurologic Subspecialties, Neuro-Oncology
Professional Organization Membership
- American Academy of Neurology
- American Association for Cancer Research
- Society of Neuro-Oncology
- Serves as a member of the NCI cancer prevention and control (CPC) Central Institutional Review Board (CIRB).
Honors & Awards
- Healthcare Hero Recipient award, Head of the Cure Foundation, Pittsburgh, 2024
- Outstanding Lecturer award, Sackler Faculty of Medicine, Tel-Aviv University, Israel, 2022
- Karp Neuro-Oncology Fellowship award, UPMC Hillman Cancer Center, Pittsburgh, 2021
- Top Performance Intern Award, Hillel-Yaffe Medical Center, Israel, 20216
- MD Graduate with First-class Honors, Hadassah Medical School, The Hebrew University of Jerusalem, 2025
Selected Recent Publications
Itay Raphael, Zujian Xiong, Chaim T Sneiderman, et al. The T cell receptor landscape of childhood brain tumors. Science Translational Medicine. 2025; 17.
Zujian Xiong, Kyle M Walsh, Chaim T Sneiderman, Michal Nisnboym. Immuno-epidemiologic mapping of human leukocyte antigen diversity across glioma patient cohorts. Neuro-Oncology. 2025; 27(6): 1628–1639.
Michal Nisnboym, Chaim T Sneiderman, et al. Assessment of anti-CD69 antibody therapy alone or in combination with anti-PD-1 in murine GBM. Expert Review of Clinical Immunology. 2025; 21(2): 239-247.
Ambika P Jaswal, Anders Josefsson, et al. Targeting tumor-infiltrating immune cells for targeted alpha therapy in gliomas: Optimization of [225Ac]Ac-DOTA-aCD11b dosing through PET-imaging. Molecular Cancer Therapeutics. 2025.
Stephen C Frederico, Itay Raphael, Michal Nisnboym, et al. Transcriptomic observations of intra and extracellular immunotherapy targets for pediatric brain tumors. Expert Review of Clinical Immunology. 2024; 11.
Itay Raphael, Anzar A Mujeeb, et al. CD200 depletion in glioma enhances antitumor immunity and induces tumor rejection. bioRxiv. 2024.
Sarah R Vincze, Ambika P Jaswal, et al. ImmunoPET imaging of TIGIT in the glioma microenvironment. Scientific Reports. 2024; 14(1): 5305.
Avi Gadoth, Michal Nisnboym, et al. Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head. Neurology Neuroimmunology and Neuroinflammation. 2023; 10(6).
Michal Nisnboym, Sarah R Vincze, et al. Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma. Cancer Research Communications. 2023; 3(7): 1173-1188.
Yahel Segal, Michal Nisnboym, et al. New Insights on DR and DQ Human Leukocyte Antigens in Anti-LGI1 Encephalitis. Neurology Neuroimmunology & Neuroinflammation. 2023; 10(3).
