Milos Ikonomovic, MD

  • Associate Professor of Neurology and Psychiatry, University of Pittsburgh
  • GRECC Research Biologist, Veterans Administration Pittsburgh HS

Dr. Ikonomovic was appointed a Research Assistant Professor in the Department of Psychiatry at the Allegheny Campus of the Medical College of Pennsylvania and Hahnemann University in 1996. In 1999 he joined Department of Psychiatry at the University of Pittsburgh School of Medicine as an Assistant Professor, and since 2008 he has been an Associate Professor of Neurology and Psychiatry at the University of Pittsburgh. Since 2010 he is also a Research Biologist in the Geriatric Research Education and Clinical Center of the VA Pittsburgh Healthcare System. His research focuses on cholinergic and synaptic changes in aging and early Alzheimer’s disease, neuropathological correlates of PET imaging, and altered metabolism of amyloid precursor protein as a link between traumatic brain injury and Alzheimer’s disease.

Education & Training

  • MD, University of Nis School of Medicine, Yugoslavia, Medicine
  • Fellow, Fidia-Georgetown University, Neurosciences

Specialized Areas Research Interests

  • Research: Synaptic and neurotransmitters dysfunction in pathological aging and early Alzheimer’s disease
  • Clinical: Chronic effects of traumatic brain injury and neuropathological links with Alzheimer’s disease and chronic traumatic encephalopathy
  • Education: Development and validation of positron emission tomography ligands for in vivo detection of amyloid, tau, and alpha-synuclein aggregates and synaptic changes

Professional Organizations Membership

  • American Academy of Neurology
  • Researchers Against Alzheimer’s
  • International CAA (Cerebral Amyloid Angiopathy) Association
  • International Society for Neurochemistry
  • Veterans Against Alzheimer’s

Honors & Awards

  • The Christopher Clark Award, for continuing advancement in the field of human amyloid imaging 

Selected Publications

Abrahamson EE, Poloyac SM, Dixon CE, Dekosky ST, Ikonomovic MD. Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats. Restor Neurol Neurosci. 2019; 37(3):245-263. PMID: 31177251.

Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve growth factor pathobiology during the progression of Alzheimer’s disease. Frontiers Neurosci, 2019 published 01 July, doi: 10.3389/fnins.2019.00533 [Epub ahead of print]

Harper MM, Hedberg-Buenz A, Herlein J, Abrahamson EE, Anderson MG, Kuehn MH, Kardon RH, Poolman P, Ikonomovic MD. Blast-mediated traumatic brain injury exacerbates retinal damage and amyloidosis in the APPswePSENd19e mouse model of Alzheimer's disease. Invest Ophthalmol Vis Sci. 2019 Jun 3; 60(7):2716-2725. PMID: 31247112.

Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. Neuropathological correlates of amyloid PET imaging in Down syndrome. Dev Neurobiol 2019; 79(7):75-766. PMID: 31379087.

Abrahamson EE, Ikonomovic MD. Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia. Exp Neurol. 2020 Feb 21;328:113257. doi: 10.1016/j.expneurol.2020.113257. [Epub ahead of print] PMID: 32092298.