Mohamed (Mo) F. Doheim, MD, PhD(c)

Research Assistant Professor of Neurology

Title(s):

Research Assistant Professor
Founding Director, NeuroPrecision Lab
NIH StrokeNet Fellow
UPMC Stroke Institute
University of Pittsburgh School of Medicine

Biographical Sketch

Dr. Mohamed (Mo) F. Doheim is a physician-scientist, clinical research methodologist, and NIH StrokeNet Fellow at the UPMC Stroke Institute, University of Pittsburgh School of Medicine. He also serves as a Research Assistant Professor of Neurology and is currently pursuing a PhD in precision care of acute ischemic stroke at Maastricht University and Master of Data Science atUniversity of Pittsburgh.

Dr. Doheim’s research centers on precision medicine, utilizing interaction subgroup analyses and machine learning to advance evidence generation in acute neurological disorders. His work primarily focuses on acute ischemic stroke, endovascular therapy, and neuroimaging. He has authored over 130 peer-reviewed publications and conference abstracts, contributing to several landmark studies and global collaborations in stroke care published in leading journals including The Lancet, The Lancet Neurology, JAMA Neurology, Stroke, Neurology, Annals of Neurology, European Stroke Journal, and The Journal of NeuroInterventional Surgery.

In addition to his research, Dr. Doheim has experience in clinical quality improvement, medical center development, and consulting on clinical trial regulations. He has presented his work at numerous national and international neurology and stroke conferences, earning multiple recognition awards and invited lectureships. He is also deeply engaged in peer education, particularly in research methodology and biostatistics. Dr. Doheim actively serves on editorial boards and contributes as a peer reviewer for high-impact journals and international grant organizations.

Education & Training

  • NIH StrokeNet Fellow, UPMC Stroke Institute, University of Pittsburgh (2025–Present)
  • PhD Candidate, Neuroscience, Maastricht University, The Netherlands (2024–Present)
  • Postdoctoral Associate, UPMC Stroke Institute, University of Pittsburgh (2023–2024)
  • Global Scholar (certificate program), Harvard Medical School Clinical Research Training Program (2018)
  • MD, Alexandria University School of Medicine, Egypt (2014–2022)

Specialized Areas of Clinical, Research and/or Education Interests

  • Computational Neuroscience, Statistical Modeling and Advanced Machine Learning
  • Acute Ischemic Stroke
  • Endovascular Therapy
  • Posterior Circulation Stroke
  • Neuroimaging and Stroke Biomarkers
  • Stroke Systems of Care and Artificial Intelligence in Stroke Triage
  • Clinical Trial Design and Meta-Analysis
  • Evidence-Based Medicine and Research Education

Professional Organization Membership

  • American Neurological Association (ANA)
  • American Heart Association (AHA)
  • Society of Vascular and Interventional Neurology (SVIN)
  • American Academy of Neurology (AAN)
  • Harvard Alumni Association (HAA)
  • Full Member, Sigma Xi Honor Society (2024)

Honors & Awards

  • Abstract of Distinction & Travel Grant, American Neurological Association (2024, 2025)
  • Young Investigator Travel Grant, International Stroke Conference (2024)
  • Travel Grants from Society of Vascular and Interventional Neurology (SVIN), LINNC America, American Neurological Association among others
  • U.S. Permanent Residency Granted under Exceptional Ability Classification – USCIS
  • Clinical Research Fellowship Award, the UPMC Stroke Institute, University of Pittsburgh School of Medicine

Selected Recent Publications

  • Doheim MF, Mohammaden MH, Abdelhamid H, Olive-Gadea M, Rodrigo-Gisbert M, Requena M, Fifi JT, Siegler JE, Ortega-Gutierrez S, Abdalkader M, Alaraj A, Hu W, Nguyen TN, Haussen DC, Nogueira RG. Individualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model. Ann Neurol. 2026 Jan 28. doi: 10.1002/ana.78168. Epub ahead of print. PMID: 41603297.

  • Doheim MF, Nguyen TN, Xiong Y, Chen HS, Bhatt NR, Wang Y, Nogueira RG. Meta-Analysis of Randomized Controlled Trials on IV Thrombolysis in Patients With Minor Acute Ischemic Stroke. Neurology. 2025 Aug 12;105(3):e213863. doi: 10.1212/WNL.0000000000213863. Epub 2025 Jul 17. PMID: 40674672.

  • Doheim MF, Knapen RRMM, Dippel DWJ, Staals J, Hofmeijer J, van Es ACGM, Coutinho JM, van der Leij C, Nogueira RG, van Oostenbrugge RJ, van Zwam WH. Association of anesthesia strategies with outcomes in endovascular treatment for distal and medium vessel occlusions: A propensity score-matched analysis of the MR CLEAN registry and meta-analysis. Eur Stroke J. 2026 Jan 1;11(1):23969873251352406. doi: 10.1093/esj/23969873251352406. PMID: 41614488.

  • Doheim MF, Bhatt N, Al-Bayati AR, Baron JC, de Andrade JBC. Editorial: Advancing precision medicine in acute stroke care: personalized treatment strategies and outcomes. Front Med (Lausanne). 2025 Nov 11;12:1718309. doi: 10.3389/fmed.2025.1718309. PMID: 41306504; PMCID: PMC12643980.

  • Doheim MF, Knapen RRMM, Staals J, Schonewille WJ, Dippel DWJ, van Es ACGM, Lingsma HF, van der Leij C, Majoie CB, Nogueira RG, van Oostenbrugge RJ, van Zwam WH; MR CLEAN Registry Investigators. Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR CLEAN Registry Study. Stroke. 2025 Oct;56(10):2866-2878. doi: 10.1161/STROKEAHA.125.051967. Epub 2025 Aug 29. PMID: 40878683; PMCID: PMC12447822.

  • Knapen RRMM*, Doheim MF*, Audebert HJ, Mont'Alverne F, Pütz V, Michel P, Liu X, Dai Q, Hu W, Tao C, Liu R, Xu P, Li C, Ji X, Jovin TG, van der Leij C, van Oostenbrugge RJ, van Zwam WH, Nogueira RG, Schonewille WJ; VERITAS collaborators. Intravenous Thrombolysis Prior to Endovascular Treatment in Basilar Artery Occlusions: A Patient Pooled Analysis of Four Randomized Controlled Trials. Cardiovasc Intervent Radiol. 2025 Dec;48(12):1869-1877. doi: 10.1007/s00270-025-04251-z. Epub 2025 Oct 27. PMID: 41145771; PMCID: PMC12665628. *Equal contribution

  • Mohammaden MH*, Doheim MF*, Dolia J, Abdelhamid H, Matsoukas S, Schuldt BR, Fifi JT, Kuybu O, Al-Bayati AR, Olive Gadea M, Rodrigo-Gisbert M, Requena M, Monteiro A, Siddiqui A, Ferreira F, Gamea A, Yu S, Siegler JE, Galecio-Castillo M, Cruz-Criollo L, Ortega-Gutierrez S, Cortez GM, Hanel RA, Hassan AE, Nguyen TN, Abdalkader M, Klein P, Salem MM, Burkhardt JK, Jankowitz B, Colasurdo M, Kan P, Hafeez M, Tanweer O, Peng S, Grossberg JA, Alaraj A, Nogueira RG, Haussen DC. Balloon guide catheter impact on angiographic and clinical outcomes in distal medium vessel occlusion stroke thrombectomy. J Neurointerv Surg. 2025 May 2:jnis-2025-023138. doi: 10.1136/jnis-2025-023138. Epub ahead of print. PMID: 40274405.*Equal contribution

  • Nogueira RG, Jovin TG, Liu X, Hu W, Langezaal LCM, Li C, Dai Q, Tao C, Mont'Alverne FJA, Ji X, Liu R, Li R, Dippel DWJ, Wu C, Zhu W, Xu P, van Zwam WH, Wu L, Zhang C, Michel P, Chen J, Wang L, Puetz V, Zhao W, Liu T, Audebert HJ, Chen Z, Pontes-Neto OM, Yi T, Moran TP, Doheim MF, Schonewille WJ; ATTENTION, BASICS, BAOCHE, and BEST Investigators. Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis. Lancet. 2025 Jan 4;405(10472):61-69. doi: 10.1016/S0140-6736(24)01820-8. Epub 2024 Dec 12. PMID: 39674187.

  • Doheim, M.F., Knapen, R.R., Dippel, D.W., Staals, J., Hofmeijer, J., van Es, A.C., Coutinho, J.M., van der Leij, C., Nogueira, R.G., van Oostenbrugge, R.J., & van Zwam, W.H. (2025). Association of anesthesia strategies with outcomes in endovascular treatment for distal and medium vessel occlusions: A propensity score-matched analysis of the MR CLEAN registry and meta-analysis. European Stroke Journal, 23969873251352406.
  • Doheim, M.F., Nguyen, T.N., Xiong, Y., Chen, H.S., Bhatt, N.R., Wang, Y., Nogueira, R.G., et al. (2025). Meta-analysis of randomized controlled trials on IV thrombolysis in patients with minor acute ischemic stroke. Neurology, 105(3), e213863.
  • Doheim, M.F., et al. (2025). Direct Endovascular vs. Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR CLEAN Registry Study. Stroke. (Accepted).
  • Doheim, M.F., et al. (2025). Adjunctive thrombolytics after successful endovascular reperfusion (ATLAS-ER): A systematic review and meta-analysis of randomized controlled trials. Annals of Neurology. (Accepted).
  • Mohammaden, M.H.*, Doheim, M.F.*, Dolia, J., Abdelhamid, H., Matsoukas, S., Schuldt, B.R., Fifi, J.T., Kuybu, O., Al-Bayati, A.R., Gadea, M.O., Rodrigo-Gisbert, M., et al. (2025). Balloon guide catheter impact on angiographic and clinical outcomes in distal medium vessel occlusion stroke thrombectomy. Journal of NeuroInterventional Surgery. *(Equal contribution).
  • Nogueira, R.G., Jovin, T.G., Liu, X., Hu, W., Langezaal, L.C.M., Li, C., Dai, Q., Tao, C., Mont'Alverne, F.J.A., Ji, X., Liu, R., Li, R., Dippel, D.W.J., Wu, C., Zhu, W., Xu, P., van Zwam, W.H., Wu, L., Zhang, C., Michel, P., Chen, J., Wang, L., Puetz, V., Zhao, W., Liu, T., Audebert, H.J., Chen, Z., Pontes-Neto, O.M., Yi, T., Moran, T.P., Doheim, M.F., Schonewille, W.J.; ATTENTION, BASICS, BAOCHE, and BEST Investigators. (2025). Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): A systematic review and individual patient data meta-analysis. The Lancet, 405(10472), 61–69. https://doi.org/10.1016/S0140-6736(24)01820-8
  • Nogueira, R.G., Doheim, M.F., Jadhav, A.P., Aghaebrahim, A., Frankel, M.R., Jankowitz, B.T., Budzik, R.F., Bonafe, A., Bhuva, P., Yavagal, D.R., & Hanel, R.A. (2024). Mode of onset modifies the effect of time to endovascular reperfusion on clinical outcomes after acute ischemic stroke: An analysis of the DAWN trial. Annals of Neurology, 96(2), 356–364.
  • Doheim, M.F., et al. (2024). Artificial intelligence-powered stroke triage system improves workflow efficiency and reduces unnecessary transfers in a large academic healthcare network. Annals of Neurology, 96, S166–S167.
  • Doheim, M.F., Al-Bayati, A.R., Bhatt, N.R., Lang, M., Starr, M., Rocha, M., ... & Nogueira, R.G. (2023). Intracranial stenting versus aggressive medical therapy for symptomatic intracranial stenosis: A meta-analysis of multicenter randomized controlled trials and an expert assessment of the current data. Interventional Neuroradiology, 15910199231206044.
  • Doheim, M.F., Hagrass, A.I., Elrefaey, M., Al-Bayati, A.R., Bhatt, N.R., Lang, M., Starr, M., Rocha, M., Gross, B., & Nogueira, R.G. (2023). From therapeutic nihilism to armamentarium: A meta-analysis of randomized clinical trials assessing safety and efficacy of endovascular therapy for acute large ischemic strokes. Interventional Neuroradiology, 15910199231170681.

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