Title(s):
Faculty Instructor (Research)
NIH StrokeNet Fellow
UPMC Stroke Institute
University of Pittsburgh School of Medicine
Biographical Sketch
Dr. Mohamed (Mo) F. Doheim is a physician-scientist, clinical research methodologist, and NIH StrokeNet Fellow at the UPMC Stroke Institute, University of Pittsburgh School of Medicine. He also serves as a Faculty Instructor in Clinical Research and is currently pursuing a PhD in Neurology at Maastricht University.
Dr. Doheim’s research centers on precision medicine, utilizing interaction subgroup analyses and machine learning to advance evidence generation in acute neurological disorders. His work primarily focuses on acute ischemic stroke, endovascular therapy, and neuroimaging. He has authored over 130 peer-reviewed publications and conference abstracts, contributing to several landmark studies and global collaborations in stroke care published in leading journals including The Lancet, The Lancet Neurology, JAMA Neurology, Stroke, Neurology, Annals of Neurology, European Stroke Journal, and The Journal of NeuroInterventional Surgery.
In addition to his research, Dr. Doheim has experience in clinical quality improvement, medical center development, and consulting on clinical trial regulations. He has presented his work at numerous national and international neurology and stroke conferences, earning multiple recognition awards and invited lectureships. He is also deeply engaged in peer education, particularly in research methodology and biostatistics. Dr. Doheim actively serves on editorial boards and contributes as a peer reviewer for high-impact journals and international grant organizations.
Education & Training
- NIH StrokeNet Fellow, UPMC Stroke Institute, University of Pittsburgh (2025–Present)
- PhD Candidate, Neuroscience, Maastricht University, The Netherlands (2024–Present)
- Postdoctoral Associate, UPMC Stroke Institute, University of Pittsburgh (2023–2024)
- Global Scholar (certificate program), Harvard Medical School Clinical Research Training Program (2018)
- MD, Alexandria University School of Medicine, Egypt (2014–2022)
Specialized Areas of Clinical, Research and/or Education Interests
- Computational Neuroscience, Statistical Modeling and Advanced Machine Learning
- Acute Ischemic Stroke
- Endovascular Therapy
- Posterior Circulation Stroke
- Neuroimaging and Stroke Biomarkers
- Stroke Systems of Care and Artificial Intelligence in Stroke Triage
- Clinical Trial Design and Meta-Analysis
- Evidence-Based Medicine and Research Education
Professional Organization Membership
- American Neurological Association (ANA)
- American Heart Association (AHA)
- Society of Vascular and Interventional Neurology (SVIN)
- American Academy of Neurology (AAN)
- Harvard Alumni Association (HAA)
- Full Member, Sigma Xi Honor Society (2024)
Honors & Awards
- Abstract of Distinction & Travel Grant, American Neurological Association (2024, 2025)
- Young Investigator Travel Grant, International Stroke Conference (2024)
- Travel Grants from Society of Vascular and Interventional Neurology (SVIN), LINNC America, American Neurological Association among others
- U.S. Permanent Residency Granted under Exceptional Ability Classification – USCIS
- Clinical Research Fellowship Award, the UPMC Stroke Institute, University of Pittsburgh School of Medicine
Selected Recent Publications
- Doheim, M.F., Knapen, R.R., Dippel, D.W., Staals, J., Hofmeijer, J., van Es, A.C., Coutinho, J.M., van der Leij, C., Nogueira, R.G., van Oostenbrugge, R.J., & van Zwam, W.H. (2025). Association of anesthesia strategies with outcomes in endovascular treatment for distal and medium vessel occlusions: A propensity score-matched analysis of the MR CLEAN registry and meta-analysis. European Stroke Journal, 23969873251352406.
- Doheim, M.F., Nguyen, T.N., Xiong, Y., Chen, H.S., Bhatt, N.R., Wang, Y., Nogueira, R.G., et al. (2025). Meta-analysis of randomized controlled trials on IV thrombolysis in patients with minor acute ischemic stroke. Neurology, 105(3), e213863.
- Doheim, M.F., et al. (2025). Direct Endovascular vs. Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR CLEAN Registry Study. Stroke. (Accepted).
- Doheim, M.F., et al. (2025). Adjunctive thrombolytics after successful endovascular reperfusion (ATLAS-ER): A systematic review and meta-analysis of randomized controlled trials. Annals of Neurology. (Accepted).
- Mohammaden, M.H.*, Doheim, M.F.*, Dolia, J., Abdelhamid, H., Matsoukas, S., Schuldt, B.R., Fifi, J.T., Kuybu, O., Al-Bayati, A.R., Gadea, M.O., Rodrigo-Gisbert, M., et al. (2025). Balloon guide catheter impact on angiographic and clinical outcomes in distal medium vessel occlusion stroke thrombectomy. Journal of NeuroInterventional Surgery. *(Equal contribution).
- Nogueira, R.G., Jovin, T.G., Liu, X., Hu, W., Langezaal, L.C.M., Li, C., Dai, Q., Tao, C., Mont'Alverne, F.J.A., Ji, X., Liu, R., Li, R., Dippel, D.W.J., Wu, C., Zhu, W., Xu, P., van Zwam, W.H., Wu, L., Zhang, C., Michel, P., Chen, J., Wang, L., Puetz, V., Zhao, W., Liu, T., Audebert, H.J., Chen, Z., Pontes-Neto, O.M., Yi, T., Moran, T.P., Doheim, M.F., Schonewille, W.J.; ATTENTION, BASICS, BAOCHE, and BEST Investigators. (2025). Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): A systematic review and individual patient data meta-analysis. The Lancet, 405(10472), 61–69. https://doi.org/10.1016/S0140-6736(24)01820-8
- Nogueira, R.G., Doheim, M.F., Jadhav, A.P., Aghaebrahim, A., Frankel, M.R., Jankowitz, B.T., Budzik, R.F., Bonafe, A., Bhuva, P., Yavagal, D.R., & Hanel, R.A. (2024). Mode of onset modifies the effect of time to endovascular reperfusion on clinical outcomes after acute ischemic stroke: An analysis of the DAWN trial. Annals of Neurology, 96(2), 356–364.
- Doheim, M.F., et al. (2024). Artificial intelligence-powered stroke triage system improves workflow efficiency and reduces unnecessary transfers in a large academic healthcare network. Annals of Neurology, 96, S166–S167.
- Doheim, M.F., Al-Bayati, A.R., Bhatt, N.R., Lang, M., Starr, M., Rocha, M., ... & Nogueira, R.G. (2023). Intracranial stenting versus aggressive medical therapy for symptomatic intracranial stenosis: A meta-analysis of multicenter randomized controlled trials and an expert assessment of the current data. Interventional Neuroradiology, 15910199231206044.
- Doheim, M.F., Hagrass, A.I., Elrefaey, M., Al-Bayati, A.R., Bhatt, N.R., Lang, M., Starr, M., Rocha, M., Gross, B., & Nogueira, R.G. (2023). From therapeutic nihilism to armamentarium: A meta-analysis of randomized clinical trials assessing safety and efficacy of endovascular therapy for acute large ischemic strokes. Interventional Neuroradiology, 15910199231170681.
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