Titles
- Associate Professor of Medicine (Geriatric Medicine)
- Associate Professor of Neurology
Biographical Sketch
Dr. Nadkarni is a geriatrician with clinical training and expertise in cognitive neurology and hospital medicine. His research includes the application of biomarkers of Alzheimer’s disease pathology and cerebral small-vessel disease measures, cognitive and gait interactions in aging, delirium and functional decline in older adults. He is a co-investigator in the Clinical Core of the Pittsburgh Alzheimer’s Disease Research Center (ADRC), Diabetes Prevention Program Outcomes Study (DPPOS), Dominantly Inherited Alzheimer Network (DIAN) besides other studies at the University of Pittsburgh. He serves as the Section Chief of Geriatrics at UPMC Shadyside Hospital and Medical Director of in-patient geriatric services at Shadyside hospital.
Education & Training
- Medical School: Jawaharlal Nehru Medical College, Karnatak University, India
- Doctoral Program: Institute of Medical Science, and the Collaborative Program in Neuroscience, University of Toronto, Toronto, Ontario, Canada
- Internal Medicine: Crozer-Chester Medical Center, Upland, PA
- Geriatric Medicine: Northwestern Memorial Hospital, Northwestern University, Chicago, IL
- Cognitive Neurology: Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
- Hospital Medicine: Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Specialized Areas of Clinical, Research and/or Educational Interests
Research: Alzheimer’s disease and related dementias, bearing of preclinical Alzheimer’s disease biomarkers and small-vessel disease on cognitive and motor outcomes in older adults, delirium, physical activity and exercise clinical trials, physical function in hospitalized older adults.
Clinical: cognitive disorders, delirium, geriatrics and hospital medicine.
Procedural privileges: Lumbar puncture procedures in adults for cerebrospinal fluid sampling.
Education: Clinical education of medical students, Internal Medicine residents and Geriatric Medicine fellows.
Board Certifications
- American Board of Internal Medicine
- Fellow, Royal College of Physicians of Canada - Internal Medicine
- Licentiate of the Medical Council of Canada
Honors & Awards
- NIH/NIA K23 Mentored Patient-Oriented Research Career Development Award
- Associate Editor, Journal of Gerontology Medical Sciences
- American Geriatric Society Outstanding Junior Investigator Award
- Alzheimer’s Disease Research Center Rising Star Nomination
- Research Day Award, Department of Medicine, University of Pittsburgh
- American Geriatrics Society New Investigator Award
- Junior Faculty Award, Aging Institute, UPMC Senior Services & University of Pittsburgh
- John A. Hartford Foundation – Center of Excellence in Geriatric Medicine Scholar Award
- Postgraduate Award, Department of Medicine, University of Toronto
Selected Recent Publications
Nadkarni NK, Levine B, McIlroy WE, Black SE. Impact of subcortical hyperintensities on dual-tasking in Alzheimer’s disease and aging. Alz Dis Assoc Dis 2012;26(1): 28-35. [PMCID: PMC3874593].
Nadkarni NK, Perera S, Snitz BE, Mathis CA, Williamson JD, DeKosky ST, Price J, Klunk WE, and Lopez OL. Association of brain amyloid-β with slow gait in elderly individuals without dementia: Influence of cognition and APOE-ε4 genotype. JAMA Neurol. 2017;74(1):82-90. [PMCID: PMC5735996].
Nadkarni NK, Lopez OL, Perera S, Studenski SA, Snitz BE, Erickson KI, Mathis CA, Nebes RD, Redfern M, Klunk WE. Cerebral amyloid deposition and dual-tasking in cognitively normal, mobility unimpaired older adults. J Gerontol A Biol Sci Med Sci 2017;72(3):431-437. [PMCID: PMC5968634].
Nadkarni NK, Levy-Cooperman N, Black SE. Functional correlates of instrumental activities of daily living in mild Alzheimer's disease. Neurobiol Aging 2012; 33(1): 53-60 [PMCID: PMC3897231].
Nadkarni NK, Perera S, Hanlon JT, Lopez OL, Studenski SA, Newman AB, Aizenstein H, Elam M, Harris TB, Kritchevsky S, Yaffe K, Rosano C for the Health ABC Study. Statin exposure and structural integrity measures in the brain of older adults in the Health ABC Study. Alzheimer’s & Dementia 2015 Jan 12. pii: S1552-5260 (14)02871-4. [PMCID: PMC4499493]
Nadkarni NK, Studenski SA, Perera S, Rosano C, Aizenstein HJ, Brach J, VanSwearingen JM. White matter hyperintensities, exercise and improvement in gait speed: Does the type of gait rehabilitation matter? J Amer Geriatr Soc 2013; 61(5): 686-693. [PMCID: PMC3874589]
Nadkarni NK, Perera S, Studenski SA, et al. Callosal hyperintensities and gait rehabilitation. Arch Phys Med & Rehab 2015; 96:1154-57 [PMCID: PMC4394027]
AGS/NIA Delirium Conference Writing Group, Planning Committee and Faculty. AGS/NIA bench-to-bedside conference: Research agenda on delirium in older adults. J Amer Geriatr Soc 2015 May;63(5):843-52. [PMCID: PMC5407494]
Hadley EC, Kuchel GA, Newman AB, Allore HG, Bartley JM, Bergeman CS, Blinov ML, Colon-Emeric CS, Dhabhar FS, Dugan LL, Dutta C, Eldadah BA, Ferrucci L, Kirkland JL, Kritchevsky SB, Lipsitz LA, Nadkarni NK, Reed MJ, Schmader KE, Sierra F, Studenski SA, Varadhan R, Walston JD, Whitson HE, Yung R, for the NIA Workshop Speakers and Participants. Report: NIA workshop on measures of physiologic resiliencies in human aging. J Gerontol A Biol Sci Med Sci 2017 Jul 1;72(7):980-990. [PMCID: PMC5861884
