Dr. Stetler’s research interests focus on the exploration of pathways leading to neuroprotection or recovery in preclinical models of stroke (cerebral ischemia). Stemming from a background in cell death, the goal of her research is to understand how bolstering molecular pathways such as DNA repair can improve stroke outcomes. Using both pharmacological interventions as well as lifestyle modifications such as caloric restriction, her research identifies both endogenous and alternative targets for therapeutic interventions.
Education & Training
- PhD, University of Pittsburgh, Neuroscience
- Post Doc, University of Pittsburgh, Neurology
Specialized Areas of Clinical, Research and/or Educational Interests
- Research: Stroke; DNA damage and repair; Cell death; White matter; Neuroprotection of caloric restriction
- Education: Cell death; Stroke
Professional Organization Membership
- American Heart Association, Stroke Council
- International Cerebral Blood Flow and Metabolism
- Society for Neuroscience
Honors & Awards
- American Heart Postdoctoral Fellowship
Selected Recent Publications
Zhang J, Zhang W, Gao X, Zhao Y, Chen D, Xu N, Pu H, Stetler RA*, Gao Y. Preconditioning with partial caloric restriction confers long-term protection against grey and white matter injury after transient focal ischemia. J Cereb Blood Flow Metab. 2019 Jul;39(7):1394-1409. doi: 10.1177/0271678X18785480. Epub 2018 Jul 4. PMID: 29972653; PMCID: PMC6668518. (*Co-corresponding author)
Yu G, Zhang K, Zhao J, Johnson JQ, Bregy VM, Chen J, Gao Y, Stetler RA. Nuances in the molecular controls of gene expression underlying preconditioning against cerebral ischemia. Conditioning Medicine. 2018, 1(3):135-142.
Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C, Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3558-67. doi: 10.1073/pnas.1606226113. Epub 2016 Jun 6. PMID: 27274063; PMCID: PMC4922172.
Stetler RA, Leak RK, Gan Y, Li P, Zhang F, Hu X, Jing Z, Chen J, Zigmond MJ, Gao Y. Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance. Prog Neurobiol. 2014 Mar;114:58-83. doi: 10.1016/j.pneurobio.2013.11.005. Epub 2014 Jan 2. PMID: 24389580; PMCID: PMC3937258.
Anne Stetler R, Leak RK, Gao Y, Chen J. The dynamics of the mitochondrial organelle as a potential therapeutic target. J Cereb Blood Flow Metab. 2013 Jan;33(1):22-32. doi: 10.1038/jcbfm.2012.158. Epub 2012 Oct 24. PMID: 23093069; PMCID: PMC3597376.