Biographical Sketch:
Sachin Gadani, MD PhD, is an Assistant Professor in the Neurology department. He completed MD and PhD degrees at the University of Virginia, and then went to the Johns Hopkins Hospital for adult neurology residency followed by neuroimmunology fellowship. He specializes in management of patients with autoimmune neurologic conditions. His basic science laboratory seeks to discover ways to halt or reverse progressive multiple sclerosis, and studies areas including meningeal immunity and the relation between inflammation and neurodegeneration.
Education & Training:
- Fellowship, Neuroimmunology, Johns Hopkins Hospital
- Residency, Adult Neurology, Johns Hopkins Hospital
- MD, University of Virginia
- PhD, University of Virginia
Specialized Areas of Clinical, Research and/or Education Interests:
Relapsing-Remitting Multiple Sclerosis, Progressive Multiple Sclerosis, Neuromyelitis Optica, MOG associated disease, Autoimmune Encephalitis, Neuroinfectious Disease, Neurodegeneration
Board Certifications:
- Adult Neurology
Professional Organization Membership:
- American Academy of Neurology
- American Neurological Association
Honors & Awards
- 2024 Career Transition Fellowship, National Multiple Sclerosis Society
- 2022 Clinician Scientist Development Award, National Multiple Sclerosis Society and the American Brain Foundation
- 2021 The Slotkin Award for Excellence in Neurological Research, Johns Hopkins School of Medicine
- 2020 Neurology Resident Brain Award, Johns Hopkins School of Medicine
- 2017 Neuroscience Outstanding Graduate Student, University of Virginia
- 2016 Neuroscience Center of Excellence Award, University of Virginia
- 2016 Eric Lothman Award for Neuroscience Research, University of Virginia
- 2015 Whitfield Randolph Award for Graduate Research, University of Virginia
- 2010 The Ralph A. Spengler Award for Excellence in Plant Science
Selected Recent Publications
T. Garton, S. Gadani, A.J Gill, and P.A. Calabresi. Neurodegeneration and demyelination in multiple sclerosis. Neuron. 2024 Jun 17;0(0).
S. Gadani and P. A. Calabresi, “The calvaria stands alone: Unique aspects of the skull bone marrow-meninges border”, Cell, vol. 186, no. 17, pp. 3524–3526, Aug. 2023, issn: 00928674.
S. Gadani, S. Singh, S. Kim, M. D. Smith, P. A. Calabresi, and P. Bhargava, “Spatial Transcriptomics of Meningeal Inflammation Reveals Variable Penetrance of Inflammatory Gene Signatures into Adjacent Brain Parenchyma”, Elife, Jul. 2023.
S. Gadani, M. Reyes-Mantilla, L. Jank, S. Harris, M. Douglas, M. D. Smith, P. A. Calabresi, E. M. Mowry, K. C. Fitzgerald, and P. Bhargava, “Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy”, EBioMedicine, vol. 73, p. 103 636, Nov. 2021, issn: 23523964.
S. Gadani, I. Smirnov, A.T. Smith, C.C. Overall, and J. Kipnis. Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury. Journal of Experimental Medicine. 2017 Feb 1;214(2):285–96.
A. J. Filiano, Y. Xu, N. J. Tustison, R. L. Marsh, W. Baker, I. Smirnov, C. C. Overall, S. Gadani, S. D. Turner, Z. Weng, S. N. Peerzade, H. Chen, K. S. Lee, M. M. Scott, M. P. Beenhakker, V. Litvak, and J. Kipnis, “Unexpected role of interferon-gamma in regulating neuronal connectivity and social behaviour”, Nature, vol. 535, no. 7612, pp. 425–429, Jul. 2016, Number: 7612, issn: 1476-4687.
S. Gadani, J. T. Walsh, I. Smirnov, J. Zheng, and J. Kipnis, “The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury”, Neuron, vol. 85, no. 4, pp. 703–709, Feb. 2015, issn: 08966273.
