Shanshan (Susan) Song, MD

  • Research Instructor, Department of Neurology

Dr. Song’s research interests focus on studying cellular/molecular mechanisms of microglia in ischemic stroke and traumatic brain injury and tissue repair. Using the advanced Cre-loxP conditional knockout technique and the state-of-the-art RNAseq bioinformatic analysis, she discovers that microglia play critical roles in neuroinflammation, phagocytosis, and microglia-oligodendrocyte crosstalk for white matter remyelination after brain injuries. Dr. Song is investigating ion transporter protein Na/H exchanger in regulating microglial metabolisms in brain tissue repair as a novel therapeutic strategy. 

Education & Training

  • MD (8-year MSTP), Southern Medical University, China, Medicine 
  • Intern, Southern Medical University, China, Medicine
  • Postdoc, University of Pittsburgh, Neuroscience

Specialized Areas of Clinical, Research and/or Educational Interests 

  • Research:  Microglia; White matter injury and repair; Bioinformatics, Ischemic stroke, and traumatic brain injury 
  • Education:  Research training and mentoring of undergraduate and graduate students

Board Certifications

  • Certified by Chinese National Medical Board of Neurology

Professional Organization Membership

  • American Heart Association
  • Society for Neuroscience
  • International Society for Cerebral Blood Flow and Metabolism
  • National Neurotrauma Society

Honors & Awards

  • Postdoctoral Fellowship, American Heart Association
  • Trainee Professional Development Award, Society for Neuroscience

Selected Recent Publications

S. Song, S. Wang, V. M. Pigott, L. M. Foley, A. Mishra, R. Nayak, W. Zhu, G. Begum, Y. Shi, K. E. Carney, T. K Hitchens, W. Gan, G. E. Shull, and D. Sun. Knockout of Na+/H+ exchanger isoform 1 in Cx3cr1-CreER microglia reduces microglial proinflammation and accelerates post-stroke brain repair and function recovery. Glia. 2018, 66(11):2279-2298.

Song S, Huang H, Guan X, Bhuiyan MIH, Tai AK, Chattopadhyay A, Chaparala S, Sun M, Stolz DB, Zhang Z, Agalliu D, Sun D, and Begum G. Targeted deletion of astrocytic Nhe1 stimulates Wnt/b-catenin-mediated BBB repair and angiogenesis after ischemic stroke [J]. Prog Neurobiol, 2020 Nov 26;101963.

Song S, Luo L, Sun B, Sun D. Roles of glial ion transporters in brain diseases. Glia. 2019 Aug 16. doi: 10.1002/glia.23699.

G. Begum, S. Song, S. Wang, H. Zhao, M. I. H. Bhuiyan, E. Li, R. Nepomuceno, Q. Ye, M. Sun, M J Calderon, D. B. Stolz, C. St. Croix, SC. Watkins, Y. Chen, P. He, G E Shull, and D. Sun. Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia. 2018 66(1):126-144. 

Luo L, Song S, Ezenwukwa CC, Jalali S, Sun B, Sun D. Ion channels and transporters in microglial function in physiology and brain diseases [J]. Neurochem Int, 2021 Jan;142:104925.