Education & Training
- University of the East-Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines. MD, Medicine.
- Neurology residency, St. Louis University School of Medicine, St. Louis, MO
- Neuro-oncology fellowship, The University of Texas M D Anderson Cancer Center, Houston, TX.
Specialized Areas of Clinical, Research and/or Education Interests
- Clinical interest: Gliomas
- Research interest: Early to late phase clinical trials for gliomas
Board Certifications
American Board of Psychiatry and Neurology, Certificate # 60324
Professional Organization Membership
- Society of Neuro-Oncology
- American Society for Clinical Oncology
- American Academy of Neurology
Selected Recent Publications
Damante, MA, Vignolles-Jeong, J, Finger, G, Kreatsoulas, D, Cua, S , Giglio, P, Ong, SS, Lonser, R,. Wu, KC, Elder, JB. Early repeat residual resection versus adjuvant therapy for incompletely resected glioblastoma: a case control study. Neurosurgery. Accepted for publication, 12/13/2024.
Alnahhas, I, Rayi, A, Slone, W, Kobalka, P Ong, S, Giglio, P Puduvalli, V; Ependymoma; pp In Neuro-Oncology Compendium for the Boards and Clinical Practice; Oxford University Press; New York, NY. 2023; Mrugala, M, Gatson, N, Kurtz, S, Nevel, K, Clarke, J. ed., 1st edition.
Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H, Kumthekar PU, Chen CC, Aiken R, Groves MD, Ong SS, Ramakrishna R, Vogelbaum MA, Khagi S, Kaley T, Melear JM, Peereboom DM, Rodriguez A, Yankelevich M, Nair SG, Puduvalli VK, Aldape K, Gao A, López-Janeiro Á, de Andrea CE, Alonso MM, Boutros P, Robbins J, Mason WP, Sonabend AM, Stupp R, Fueyo J, Gomez-Manzano C, Lang FF, Zadeh G. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med. 2023 Jun;29(6):1370-1378. doi: 10.1038/s41591-023-02347-y. Epub 2023 May 15. PMID: 37188783; PMCID: PMC10287560.
Matsui, JK, Perlow, HK, Ritter, AR, Upadhyay, R, Raval, RR, Thomas, EM, Beyer, SJ, Pillainayagam, C, Goranovich, J, Ong, S, Giglio, P, Palmer, JD. Small Molecules and Immunotherapy Agents for Enhancing Radiotherapy in Glioblastoma. Biomedicines 2022, 10(7), 1763.
Haley K. Perlow Alexander Yaney Michael Yang Brett G. Klamer Jennifer K. Matsui Raju R. Raval Dukagjin M. Blakaj Andrea Arnett Sasha Beyer James Bradley Elder Mario Ammirati Russell Lonser Douglas Hardesty Shirley Ong Joshua D. Palmer Dose-escalated accelerated hypofractionation for elderly or frail patients with a newly diagnosed glioblastoma Journal of Neuro-Oncology 11 Jan 2022.
Haley K. Perlow Michael Yang Brett G. Klamer Raju R. Raval Dukagjin M. Blakaj Andrea Arnett Sasha Beyer John Grecula Mario Ammirati James Bradley Elder Russell Lonser Douglas Hardesty Shirley Ong Pierre Giglio Joshua D. Palmer. Hypofractionated Dose-Escalation for Elderly Patients With a Newly Diagnosed Glioblastoma Improves Survival. Research Square 25 Oct 2021.
Appaji Rayi, Iyad Alnahhas, Shirley Ong, Pierre Giglio, Vinay Puduvalli. Targeted Therapy for BRAF Mutant Brain Tumors Current Treatment Options in Oncology 06 Oct 2021.
Andrew Sloan Robin Arthur Buerki Christopher Murphy Andrea T. Kelly Prakash Ambady Michael Brown Nicholas Butowski Robert Cavaliere William T Curry Annick Desjardins Lisa Franklin Henry S. Friedman Matthias Gromeier LeAnn Jackson Lori Mixson Shirley Ong Garrett Nichols LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma. Journal of Clinical Oncology 20 May 2021.
Iyad Alnahhas, Appaji Rayi, Maria del Pillar Guillermo Prieto Eibl, Shirley Ong, Pierre Giglio, Vinay Puduvalli. Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDHwt glioblastoma. Neuro-Oncology Advances, Volume 3, Issue 1, January-December 2021, vdab127. 01 Jan 2021.
Iyad Alnahhas, Mouaz Alsawas, Appaji Rayi, Joshua d. Palmer, Raju R. Raval, Shirley Ong, Pierre Giglio, Mohammad Hassan Murad, Vinay Puduvalli. Erratum to: Characterizing Benefit from Temozolomide in MGMT Promoter Unmethylated and Methylated Glioblastoma: A Systematic Review and Meta-analysis. Neuro-Oncology Advances, Volume 3, Issue 1, January-December 2021, vdab095. 01 Jan 2021.
Alnahhas I; Rayi, A; Palmer, J; Raval, R; Folefac, E; Ong, SS; Giglio, P; Puduvalli, V. “NCMP-01. The Role of Vascular Endothelial Growth Factor Receptor Inhibitors in Preventing Radiation Necrosis: A Retrospective Cohort Study.” Neuro-Oncology, Volume 22, Issue Supplement_2, November 2020, Page ii123.
Andrea T. Kelly Prakash Ambady Michael Brown Nicholas Butowski Robert Cavaliere William T Curry Annick Desjardins Lisa Franklin Henry Friedman Matthias Gromeier LeAnn Jackson Lori Mixson Shirley Ong Dina M. Randazzo et al Garrett Nichols. Abstract CT240: LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma. Cancer Research 01 July 2021.
Alnahhas I., Rayi A, Ong, SS, Giglio P, Puduvalli V, Management of gliomas in patients with Lynch Syndrome, Neuro-Oncology. Volume 23, Issue 1, January 2021, Pages 167–168.
Alnahhas, Iyad; Rayi, Appaji; Thomas, Diana; Ong, Shirley; Giglio, Pierre; Puduvalli, Vinay. False-positive 1p/19q Testing Results in Gliomas Clinical and Research Consequences. American Journal of Clinical Oncology 43(11): p 802-805, November 2020.
Iyad Alnahhas, Mouaz Alsawas, Appaji Rayi, Joshua D Palmer, Raju Raval, Shirley Ong, Pierre Giglio, Mohammad Hassan Murad, Vinay Puduvalli. Characterizing benefit from temozolomide in MGMT promoter unmethylated and methylated glioblastoma: a systematic review and meta-analysis. Neuro-Oncology Advances, vol 2, issue 1, January- December 2020, vdaa082. 30 Oct 2020.
Robert Aiken, Clark Chen, Timothy Cloughesy, Howard Colman, Mariza Daras, Morris Groves, Simon Khagi, Priya Kumthekar, Frederick Lang, Farshad Nassiri, Shirley Ong, Rohan Ramakrishna, Adam Sonabend, Michael Vogelbaum, Gelareh Zadeh, Laura Agensky, Carin Bidwell, Barry Watkins, Frank Tufaro, Joanna Peterkin, ATIM-33. Interim Results of a Phase II Multi-center Study of Oncoloytic Adenovirus DNX-2401 with Pembrolizumab for Recurrent Glioblastoma; Captive Study (KEYNOTE-192), Neuro-Oncology, Volume 21, Issue Supplement_6, November 2019, Pages vi8–vi9.
Gelareh Zadeh, Frederick Lang, Mariza Daras, Timothy Cloughesy, Howard Colman, Shirley Ong, Rohan Ramakrishna, Michael Vogelbaum, Morris Groves, Farshad Nassiri, L Sue Frederick, Karen Gammon, Sheila Fulling, Kari Anne Rowland, Erin Mitchell, Brett Ewald, Frank Tufaro, Joanna Peterkin, ATIM-24. Interim Results of a Phase II Multicenter Study of the Conditionally Replicative Oncolytic Adenovirus DNX-2401 with Pembrolizumab (Ketruda) for Recurrent Glioblastoma: CAPTIVE Study (KEYNTE-192), Neuro-Oncology, Volume 20, Issue suppl_6, 1 November 2018, Page vi6.
Abdalla, A; Herlopian, A; Ravilla, R; Bansal, M; Chandra-Reddy S, Mahmoud, F; Ong, SS; Gokden, M; Hutchins, L. “Ipilimumab induced- necrotic myelopathy in a patient with metastatic melanoma: A case report and review of literature”. J Oncol Pharm Pract. 2015 Feb 23.
Jacob, S; Gupta, H; Nikolic, D; Gundogdu, B; Ong, SS. “Central and Extrapontine Myelinolysis, The Great Masquerader: An Autopsy Case Report”. Case Reports in
Neurological Medicine,2014; 2014:745347.Epub 2014 Mar 4.
Ong SS.; Bruner, J.; Schellingerhout, D.; Puduvalli, VK. “Papillary Endothelial Hyperplasia Presenting As Recurrent Malignant Glioma”. Journal of Neuro-Oncology, 2011:102(3), 491-498.
