Dr. Graham’s research interests include neuronal cell death mechanisms in stroke, traumatic brain injury and neurodegenerative diseases. His basic science research concerns the role of oxidative stress and lipids in neuronal apoptosis and recovery after ischemia and trauma. Specifically, much of Dr. Graham’s research is currently focused on the role of cyclopentenone prostaglandins and other oxidized lipids in neuronal cell death and dysfunction. In recent years, these efforts have focused on the lipid modification of UCHL1 and its role in injury and recovery after stroke and TBI. As Director of the Pittsburgh Geriatric Research Education and Clinical Center, he oversees a multidisciplinary center that conducts basic and clinical research in aging and aging-related diseases.
Education & Training
- MD, University of Texas Medical School at Houston, Medicine
- PhD, University of Texas Graduate School of Biomedical Sciences, Biomedical Sciences
- Resident, Baylor College of Medicine, Internal Medicine
- Resident, University of California San Francisco, Neurology
- Post Doc, University of California San Francisco, Neurology and Neuroscience
Specialized Areas of Clinical, Research and/or Educational Interests
- Research: Reactive lipid species, ubiquitin proteasome pathway, cerebral ischemia, traumatic brain injury, neuronal repair and recovery
- Clinical: Stroke
- Education: Clinician-Scientist Career Development
- American Board of Psychiatry and Neurology
Professional Organization Membership
- American Academy of Neurology
- American Heart Association
- Society for Neuroscience
Honors & Awards
- Award for Excellence for Teaching, Department of Neurology, University of Pittsburgh
- Fellow, American Heart Association
- Fellow, American Academy of Neurology
- Federal Executive Board, Gold Award of Excellence,
- Outstanding Contribution to Science (Medical)
- V.A. Pittsburgh Healthcare System, Outstanding Commitment to Excellence in Research to Improve Veterans' Lives
Selected Recent Publications
Liu H, Li W, Rose ME, et al. The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury. Cell Death Dis 6: e1966, 2015.
Liu H, Rose ME, Ma X, Culver S, Dixon CE, Graham SH. In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury. PLoS One 12: e0178049, 2017.
Graham SH, Liu H. Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia. Ageing Res Rev 34: 30-38, 2017.
Liu H, Povysheva N, Rose ME, Mi Z, Banton JS, Li W, Chen F, Reay DP, Barrionuevo G, Zhang F, Graham SH. Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia. Proc Natl Acad Sci U S A epub 2/15, 2019.