Dr. Shi’s research interest centers on the role of myeloid cells after ischemic and traumatic brain injuries, and has two major directions. The first focus is to elucidate genome-wide transcriptomic changes occurring in myeloid cells after brain injury with cutting-edge high-throughput sequencing and single-cell analytic tools. The second focus is to identify molecular targets to manipulate the function of myeloid cells to promote repair and recovery after ischemic stroke and traumatic brain injury. Dr. Shi received funding by the NIH/National Institute of Neurological Disorders and Stroke (NINDS), American Heart Association, and UPMC for her research, and has over 60 peer-reviewed publications.
Education & Training
- PhD, Neuroscience, University of Wisconsin-Madison
- MD, Peking University, Medicine
Specialized Areas of Clinical, Research and/or Educational Interests
Research: Bioinformatics; Ischemic stroke; Neuroinflammation; Traumatic brain injury
Education: Research Training and Mentoring
Professional Organization Membership
- American Heart Association
- International Society of Cerebral Blood Flow and Metabolism
Honors & Awards
- Robert G. Siekert New Investigator Award in Stroke, American Heart Association
- Competitive Medical Research Fund, University of Pittsburgh Medical Center (UPMC)
- Scientist Development Grant, American Heart Association
- Mordecai Y. T. Globus New Investigator Award in Stroke, American Heart Association
- Stroke Basic Science Award, American Heart Association
Wang R, Pu H, Ye Q, Jiang M, Chen J, Zhao J, Li S, Liu Y, Hu X, Rocha M, Jadhav AP, Chen J, Shi Y. Transforming Growth Factor Beta-Activated Kinase 1-Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke. Stroke. 2020 Mar;51(3):975-985. doi: 10.1161/STROKEAHA.119.028398. Epub 2020 Feb 12. PMID: 32078472.
Wang R, Liu Y, Ye Q, Hassan SH, Zhao J, Li S, Hu X, Leak RK, Rocha M, Wechsler LR, Chen J, Shi Y. RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke. J Cereb Blood Flow Metab. 2020 Apr;40(4):720-738. doi: 10.1177/0271678X19888630. Epub 2019 Nov 13. PMID: 31722596; PMCID: PMC7168800.
Zhang W, Zhao J, Wang R, Jiang M, Ye Q, Smith AD, Chen J, Shi Y. Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain. CNS Neurosci Ther. 2019 Dec;25(12):1329-1342. doi: 10.1111/cns.13256. Epub 2019 Nov 7. PMID: 31697040; PMCID: PMC6887920.
Shi Y, Jiang X, Zhang L, Pu H, Hu X, Zhang W, Cai W, Gao Y, Leak RK, Keep RF, Bennett MV, Chen J. Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1243-E1252. doi: 10.1073/pnas.1621174114. Epub 2017 Jan 30. PMID: 28137866; PMCID: PMC5320958.
Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury. Nat Commun. 2016 Jan 27;7:10523. doi: 10.1038/ncomms10523. Erratum in: Nat Commun. 2020 Aug 25;11(1):4335. PMID: 26813496; PMCID: PMC4737895.