Yejie (Amy) Shi, MD, PhD

  • Research Assistant Professor of Neurology

Dr. Shi’s research interest centers on the role of myeloid cells in post-stroke brain injury and recovery, and have two major directions. The first focus is to elucidate genome-wide transcriptomic changes occurring in myeloid cells after ischemic stroke with cutting-edge high-throughput sequencing and single-cell analytic tools. The second focus is to identify molecular targets to manipulate the functions of myeloid cells in the post-stroke brain to promote repair and recovery. Dr. Shi received funding by the American Heart Association and UPMC for her research, and has over 50 peer-reviewed publications. 

Education & Training

  • MD, Peking University, Medicine
  • PhD, Neuroscience, University of Wisconsin-Madison

Specialized Areas of Clinical, Research and/or Educational Interests 

Research: Bioinformatics; Cellular and molecular mechanisms of ischemic brain injury; Neuroinflammation; Neurovascular protection and repair; Stroke (basic science)

Professional Organization Membership

  • American Heart Association
  • International Society of Cerebral Blood Flow and Metabolism

Honors & Awards

  • Competitive Medical Research Fund, University of Pittsburgh Medical Center (UPMC) 
  • Scientist Development Grant, American Heart Association
  • Mordecai Y. T. Globus New Investigator Award in Stroke, American Heart Association
  • First Place, Veterans Research Foundation of Pittsburgh Young Investigator Poster Contest
  • Stroke Basic Science Award, American Heart Association

Selected Publications

Wang R, Pu H, Ye Q, Jiang M, Chen J, Zhao J, Li S, Liu Y, Hu X, Rocha M, Jadhav AP, Chen J, Shi Y (2020). Transforming growth factor beta-activated kinase 1-dependent microglial and macrophage responses aggravate long-term outcomes after ischemic stroke. Stroke. 51(3):975-985.

Wang R, Liu Y, Ye Q, Hassan SH, Zhao J, Li S, Hu X, Leak RK, Rocha M, Wechsler LR, Chen J, Shi Y (2020). RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke. J Cereb Blood Flow Metab. 40(4): 720-738.

Zhang W, Zhao J, Wang R, Jiang M, Ye Q, Chen J, Shi Y (2019). Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain. CNS Neurosci Ther. 25(12):1329-1342. 

Shi Y, Jiang X, Zhang L, Pu H, Hu X, Zhang W, Cai W, Gao Y, Leak RK, Keep RF, Bennett MV, Chen J (2017). Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury. Proc Natl Acad Sci U S A. 114(7):E1243-E1252. 

Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji X, Chen J (2016). Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury. Nat Commun. 7:10523.